1. Do Now: What can go wrong? 2. ______________ 4. _______________ 1. _____________ 3. _____________ 6. _____________ 5. _______________

2. 3. _____________3. Initial Segment – process inputs Quick Review – Neuron Parts & Function 2. ______________ 4. _______________ 1. _____________ 6. _____________ 5. _______________ 1. Dendrites – receive signals 2. Cell Body – maintains cell life 4. Axon – send signals electrically and provides transportation route 6. Synapse – send signals chemically 5. Myelin – insulate axon

3. What can go wrong? 1. Dendrites – receive signals 3. Initial Segment – process inputs 6. Synapse – send signals chemically 5. Myelin – insulate axon 4. Axon – send signals electrically and provides transportation route 2. Cell Body – maintains cell life

4. Gabby – Congenital analgesia Normal PatientGabby X X

5. Mitchell – Hereditary Spastic Paraplegia (HSP) nucleus synapse HSP defects with Kinesin

6. Albert – Diabetic Neuropathy

7. Allison – Charcot-Marie Tooth Disease (CMTD) Champagne Legs Defects with Peripheral Myelin

8. Maria – Multiple Sclerosis (MS)

9. Yumiko – Alzheimer’s Disease (AD)