1. Chapter 8: Plasticity in the Nervous System

2. Concept of Plasticity  What does plasticity mean? Guesses?

3. 1. Closed head injury vs. open head injury 2. Cerebrovascular events (stroke)  There are two types of stroke: a) Ischemia b) Hemorrhage Types of Brain Injury

4. Cellular ‘events’ Post-Injury 1. Axonal re-growth (not new cell) 2. Sprouting 3. Super-sensitivities –  Disuse  Denervation

5. How do we Research Brain Injury? 1. Study people with injury 2. Use of animals

6. Important Factors in Recovery 1. Type & extent of damage 2. Age when injury is sustained

7. Screw-ups in Recovery 1. Damaged axons can reconnect to the wrong target 2. Phantom Limb

8. Specific Therapies for CNS Injury 1. Behavioral intervention 2. Rehabilitation 3. Drugs 4. Cell replacement??

9. Next Time: Exam #1 on Chapters 1-3, 7-8