1. Essentials of Human Anatomy & Physiology Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slides 6.1 – 6.17 Seventh Edition Elaine N. Marieb Chapter 6 The Muscular System: Physiology Lecture Slides in PowerPoint by Jerry L. Cook

2. The Muscular System  Function of muscular system: 1.Produce movement 2.Maintain posture 3.Generate heat 4.Stabilize joints  Function of muscle = contraction  Three basic muscle types are found in the body (memorize chart pg. 163)  Skeletal muscle  Cardiac muscle  Smooth muscle

3. Properties of Skeletal Muscle Activity  Contractility – ability to shorten when an adequate stimulus is received  Irritability – ability to receive and respond to a stimulus

4. Nerve Stimulus to Muscles  Skeletal muscles must be stimulated by a nerve to contract  Motor unit  One neuron  Muscle cells stimulated by that neuron Figure 6.4a

5. Nerve Stimulus to Muscles  Neuromuscular junctions – association site of nerve and muscle Figure 6.5b

6. Nerve Stimulus to Muscles  Synaptic cleft – gap between nerve and muscle  Nerve and muscle do not make contact  Area between nerve and muscle is filled with interstitial fluid Figure 6.5b

7. Transmission of Nerve Impulse to Muscle  Neurotransmitter – chemical released by nerve upon arrival of nerve impulse  The neurotransmitter for skeletal muscle is acetylcholine  Neurotransmitter attaches to receptors on the sarcolemma  Sarcolemma becomes permeable to sodium (Na + )

8. Transmission of Nerve Impulse to Muscle  Sodium rushing into the cell generates an action potential  Once started, muscle contraction cannot be stopped  Sarcoplasmic reticulum releases Ca +2 ions into the muscle cytoplasm causing tropomyosin to relase the actin binding sites

9. The Sliding Filament Theory of Muscle Contraction  Activation by nerve causes myosin heads (cross bridges) to attach to binding sites on the thin filament  Myosin heads then bind to the next site of the thin filament Figure 6.7

10. The Sliding Filament Theory of Muscle Contraction  This continued action causes a sliding of the myosin along the actin  The result is that the muscle is shortened (contracted) Figure 6.7

11. The Sliding Filament Theory –see printed notes Figure 6.8

12. By the way, here’s how smooth muscle contracts.

13. Contraction of a Skeletal Muscle  Muscle fiber contraction is “all or none”  Within a skeletal muscle, not all fibers may be stimulated during the same interval  Different combinations of muscle fiber contractions may give differing responses  Graded responses – different degrees of skeletal muscle shortening

14. Types of Muscle Contractions  Isotonic contractions  Myofilaments are able to slide past each other during contractions  The muscle shortens  Isometric contractions  Tension in the muscles increases  The muscle is unable to shorten (because muscle pitted against immovable object)

15. Contraction of a Skeletal Muscle  Graded responses can be produced two ways: 1. Change the frequency of muscle stimulation 2. Change the number of muscle cells stimulated

16. Types of Graded Responses  Twitch  Single, brief contraction  Not a normal muscle function

17. Types of Graded Responses  Tetanus (summing of contractions)  One contraction is immediately followed by another  The muscle does not completely return to a resting state  The effects are added Figure 6.9a, b

18. Types of Graded Responses  Unfused (incomplete) tetanus  Some relaxation occurs between contractions  The results are summed Figure 6.9a, b Figure 6.9c,d

19. Types of Graded Responses  Fused (complete) tetanus  No evidence of relaxation before the following contractions  The result is a sustained muscle contraction Figure 6.9a, b Figure 6.9c,d

20. Muscle Response to Strong Stimuli  Muscle force depends upon the number of fibers stimulated  More fibers contracting results in greater muscle tension  Muscles can continue to contract unless they run out of energy

21. Energy for Muscle Contraction  Initially, muscles used stored ATP for energy  Bonds of ATP are broken to release energy  Only 4-6 seconds worth of ATP is stored by muscles  After this initial time, other pathways must be utilized to produce ATP

22. Energy for Muscle Contraction  Direct phosphorylation  Muscle cells contain creatine phosphate (CP)  CP is a high-energy molecule  After ATP is depleted, ADP is left  CP transfers energy to ADP, to regenerate ATP  CP supplies are exhausted in about 20 seconds Figure 6.10a

23. Energy for Muscle Contraction  Aerobic Respiration  Series of metabolic pathways that occur in the mitochondria  Glucose is broken down to carbon dioxide and water, releasing energy (ATP)  This is a slower reaction that requires continuous oxygen Figure 6.10c

24. Energy for Muscle Contraction  Anaerobic glycolysis  Reaction that breaks down glucose without oxygen  Glucose is broken down to pyruvic acid to produce some ATP  Pyruvic acid is converted to lactic acid Figure 6.10b

25. Energy for Muscle Contraction  Anaerobic glycolysis (continued)  This reaction is not as efficient, but is fast  Huge amounts of glucose are needed  Lactic acid produces muscle fatigue Figure 6.10b

26. Muscle Fatigue and Oxygen Debt  When a muscle is fatigued, it is unable to contract  The common reason for muscle fatigue is oxygen debt  Oxygen must be “repaid” to tissue to remove oxygen debt  Oxygen is required to get rid of accumulated lactic acid  Increasing acidity (from lactic acid) and lack of ATP causes the muscle to contract less

27. Two* Types of Muscle Fibers Type 1 a. AKA Slow twitch b. oxidative c. Generally found in higher proportion in muscles reponsible for posture Type 2 a. AKA Fast twitch b. Type 2A = oxidative and glycolytic Type 2B = glycolytic c. Generally found in higher proportion in muscle that give short bursts of activity

28. Effects of Exercise on Muscle Results of increased muscle use  Increase in muscle size  Increase in muscle strength  Increase in muscle efficiency  Muscle becomes more fatigue resistant Normal adult skeletal muscle cells do not undergo cell division  Inactive adult stem cells are present just deep to the external lamina of a muscle fiber  Stems cells become active following muscle tissue destruction

29. Aerobic (Endurance) Exercise vs. Resistance Exercise: What is the difference?  Resistance Exercise: increased muscle size and strength  Aerobic Exercise: has many benefits besides those to the skeletal muscles (makes metabolism more efficient, improves digestion and elimination, strengthens skeleton, heart enlarges, fat deposits cleared from blood vessels, lungs become more efficient)

30. Muscle Tone  Some fibers are contracted even in a relaxed muscle  Different fibers contract at different times to provide muscle tone  The process of stimulating various fibers is under involuntary control