1. D. James Cooper Russell Gruen National Health & Medical Research Council (NHMRC) Funding dates: 2014-2016

4. supported v. c

6. High impact TBI research for 15 yearsHigh impact TBI research for 15 years

8. Current multicenter RCTs N=500 Severe TBI, Prophylactic hypothermia Early/prolonged/slow N=600 Mod /severe TBI Erythropoietin

9. Overview Primary research question or hypothesis  Comparative Effectiveness Research approach will identify most effective clinical interventions for TBI pts world-wide Number of subjects  100 ICU at Alfred Hospital; (1800 ICU in CENTER) Study design  Prospective longitudinal observational cohort study  Australian ICU stratum sites within global CER  Aus: Trauma system, multi-discipline ICU, intensivist led, high nursing ratios, outcomes Registries, collaborative research ethic  Living reviews / translation hub  Complete Australian TBI RCTs with Europe sites

10. Participation in InTBIR What are your expectations for joining InTBIR?  Help maximize strength of global TBI collaboration  Maximize TBI patient diversity within InTBIR  Working within InTBIR will enable Global results to best inform our management, speed of translation, and guide research

11. Participation in InTBIR How might your participation contribute to achieving the mission of InTBIR ?  Assist patient recruitment in ICU stratum of CENTER  Assist generalizability European findings to another first world center  Broaden practice variation for the world-wide CER  Link Australia into the global collaboration  Compare Australian structures / therapies / outcomes with other world centers

12. Participation in InTBIR Do you already have an ongoing collaboration with InTBIR projects? What successes and issues so far?  Collaboration with CENTER-TBI  Success: Collaborative NHMRC-EC Funding  Issues: Funding cut by 2/3 ($375K/3 yrs). CRE grant for TBI research and OzENTER – not successful.  Monash Co-ordination Centre and Translation Centre  Planning for modified start up at Alfred late 2014  MRI/DTI technical issues tested over 2 years

13. Participation in InTBIR Is the funding agency currently supporting your project open to international collaboration under the umbrella of InTBIR?  In principle - Yes.