1. Endocrine System

2. Endocrine glands are composed of cells that secrete: – Hormones amino acid derivatives peptides and proteins steroids

3. Hormones act by attaching to receptors of specific target cells

4. Function of endocrine system: – homeostasis – growth and development

5. Endocrine Glands Hypothalamus – oxytocin production – ADH production – production and secretion of regulatory hormones for anterior pituitary

6. Pituitary (hypophysis) – posterior pituitary oxytocin secretion ADH secretion

8. Pituitary (hypophysis) – anterior pituitary Tropic hormones – TSH – ACTH – Gonadotropins: FSH, LH Prolactin Growth hormone

10. – all anterior pituitary hormones are regulated by hypothalamic hormones – regulation dependent upon hypophyseal portal system

12. Thyroid Gland

13. – T 4 and T 3 : released by thyroid follicles – calcitonin: released by C cells

15. Parathyroid glands

17. – PTH

18. Adrenal Gland

20. – Adrenal cortex mineralocorticoids glucocorticoids adrenal androgens – Adrenal medulla E and NE

21. Endocrine pancreas – Islets of Langerhans glucagon: from alpha cells insulin: from beta cells somatostatin: from delta cells

23. Pineal gland – melatonin Heart – ANP Kidney – renin – EPO

24. Thymus Gland – thymosin

25. Reproductive System – Testes testosterone inhibin – Ovaries estrogens progesterone

26. Endocrine Disorders Acromegaly

27. Endocrine Disorders, continued Acromegaly Gigantism

29. Endocrine Disorders, continued Acromegaly Gigantism Pituitary Dwarfism

30. Endocrine Disorders, continued Goiter

31. Endocrine Disorders, continued Goiter

32. Endocrine Disorders Grave’s disease

33. Endocrine Disorders, continued Cretinism

34. Endocrine Disorders, continued Cushing’s disease

35. Endocrine Disorders, continued Cushing’s disease Addisons disease

37. Endocrine Disorders, continued Type I diabetes Type II diabetes