1. Endocrine (Overview) Ⅰ Introduction 1. Endocrine System 2. Paracrine and endocrine actions 3. Chemical Composition Ⅱ Mechanisms of Hormone Actions 1. Hormone Receptors a. cell surface receptors b. nuclear receptors 2. Regulation of Reposiveness to hormone 3. Interactions between Hormone Response Systems Ⅲ Endocrine and Nervous System Relationship: Neuroendocrinology 1. Neurotransmitter 2. Hypothalamis-pituitary relationship a. Anterior pituitary b. Posterior pituitary c. Pineal gland Ⅳ Gene Expression and Recombinant DNA in Endocrinology and Metabolism

2. Ⅴ Evolution of the Endocrine Systems 1. Cellular control networks and the origins of regulatory chemicals 2. Origins of hormones 3. Intracellular communication 4. Evolution of genes involved in the endocrine system 5. Integrative networks 6. Evolution of endocrine glands Ⅵ Hormone Synthesis, Release and Transport 1. Synthesis and Release 2. Transport a. unbound transport b. bound transport Ⅶ Metabolism and Elimination of Hormones Ⅷ Regulation of the Endocrine System Ⅸ Physiological Actions of Hormones A. Developmental effects B. Cell growth and cancer C. Central nervous System Effects D. Metabolism E. Cardiovascular and Renal function F. Ionic and osmotic Regulation G. Skeletal Function H. Reproductive Function I. Immunologic Function

3. Ⅰ Introduction 1. Endocrine System Endocrine (Overview)

4. Ⅱ Mechanisms of Hormone Actions 1. Hormone Receptors a. cell surface receptors b. nuclear receptors 2. Regulation of Reposiveness to hormone

5. 2. Paracrine and endocrine actions 3. Chemical Composition

7. 3. Interactions between Hormone Response Systems

9. Ⅲ Endocrine and Nervous System Relationship: Neuroendocrinology 1. Neurotransmitter 2. Hypothalamus-pituitary relationship a. Anterior pituitary b. Posterior pituitary

10. Ⅴ Evolution of the Endocrine Systems c. Pineal gland

11. Ⅳ Gene Expression and Recombinant DNA in Endocrinology and Metabolism

12. 1. Cellular control networks and the origins of regulatory chemicals 2. Origins of hormones 3. Intracellular communication 4. Evolution of genes involved in the endocrine system 5. Integrative networks 6. Evolution of endocrine glands Ⅵ Hormone Synthesis, Release and Transport 1. Synthesis and Release 2. Transport a. unbound transport b. bound transport Ⅶ Metabolism and Elimination of Hormones Ⅷ Regulation of the Endocrine System Ⅸ Physiological Actions of Hormones A. Developmental effects B. cell growth and cancer C. Central nervous System Effects D. Metabolism E. Cardiovascular and Renal function F. Ionic and osmotic Regulation

13. G. Skeletal Function H. Reproductive Function I. Immunologic Function