1. Male Genital Tract 1, Case 4 62-year-old man presents with gross hematuria.

2. Identify the organ(s) Identify the structures Describe the gross pathology

3. Urothelial Cell Carcinoma of the Bladder The autopsy specimen consists of the urinary bladder and attached prostate. The bladder is open in the midline through the prostatic urethra and the anterior wall of the bladder. Note the papillary urothelial cell carcinoma grew from the bladder wall into the lumen. A – Trabeculation B – Mass/Carcinoma C – Prostatic urethra D – Prostate

4. Describe the histologic findings

5. Papillary structures composed of a fibrovascular core covered by a transitional cell epithelium with an increased number of cell layers and loss of polarity, indicative of urothelial carcinoma. Fibrovascular Core

6. Describe the high power histologic findings Fibrovascular core Cells with hyperchromatic nuclei and nuclear atypia Loss of organized polarity of urothelial cells