1. 1 Chapter 15 Lecture Outline See PowerPoint Image Slides for all figures and tables pre-inserted into PowerPoint without notes. Copyright (c) The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

2. 2 Autonomic Nervous System and Visceral Reflexes  Autonomic nervous system (ANS) general properties general properties anatomy anatomy  Autonomic effects on target organs  Central control of autonomic function

3. 3 ANS - General Properties  Motor nervous system controls glands, cardiac and smooth muscle also called visceral motor system also called visceral motor system  Regulates unconscious processes that maintain homeostasis BP, body temperature, respiratory airflow BP, body temperature, respiratory airflow  ANS actions are automatic biofeedback techniques biofeedback techniques train people to control hypertension, stress and migraine headachestrain people to control hypertension, stress and migraine headaches

4. 4 Visceral Reflexes  Unconscious, automatic responses to stimulation of glands, cardiac or smooth muscle 1. Receptors detect internal stimuli -- stretch, blood chemicals, etc. detect internal stimuli -- stretch, blood chemicals, etc. 2. Afferent neurons connect to interneurons in the CNS connect to interneurons in the CNS 3. Efferent neurons carry motor signals to effectors carry motor signals to effectors ANS is the efferent neurons of these reflex arcs ANS is the efferent neurons of these reflex arcs 4. Effectors glands, smooth or cardiac muscle glands, smooth or cardiac muscle  ANS modifies effector activity

5. 5 Visceral Reflex to High BP  High blood pressure detected by arterial stretch receptors (1), afferent neuron (2) carries signal to CNS, efferent (3) signals travel to the heart (4), heart slows reducing BP

6. 6 Divisions of ANS  Two divisions innervate same target organs may have cooperative or contrasting effects may have cooperative or contrasting effects 1. Sympathetic division prepares body for physical activity prepares body for physical activity increases heart rate, BP, airflow, blood glucose levels, etcincreases heart rate, BP, airflow, blood glucose levels, etc 2. Parasympathetic division calms many body functions and assists in bodily maintenance calms many body functions and assists in bodily maintenance digestion and waste elimination digestion and waste elimination  Autonomic tone is the normal rate of activity that represents the balance of the two systems  Effects of each depend upon neurotransmitters released

7. 7 Somatic versus Autonomic Pathways ANS = 2 neurons from CNS to effectors presynaptic neuron cell body in CNS postsynaptic neuron cell body in peripheral ganglion

8. 8  Origin of presynaptic neurons lateral horns of spinal cord (T1-L2) lateral horns of spinal cord (T1-L2)  Sympathetic chain ganglia (paravertebral) 3 cervical, 11 thoracic, 4 lumbar, 4 sacral and 1 coccygeal ganglia 3 cervical, 11 thoracic, 4 lumbar, 4 sacral and 1 coccygeal ganglia white and gray communicating rami suspend ganglia from spinal nerve white and gray communicating rami suspend ganglia from spinal nerve pathways of preganglionic fibers pathways of preganglionic fibers 1.enter ganglia and synapse on postganglionic cell 2.travel to higher or lower ganglia and synapse 3.pass through chain without synapsing to reach collateral ganglia via splanchnic nerves Sympathetic Nervous System

9. 9  Neuronal divergence predominates each preganglionic cell branches and synapses on multiple postganglionic cells each preganglionic cell branches and synapses on multiple postganglionic cells produces widespread effects on multiple organs produces widespread effects on multiple organs Sympathetic Nervous System

10. 10 Efferent Pathways

11. 11 Preganglionic Pathways

12. 12 Ganglia and Abdominal Aortic Plexus

13. 13 Sympathetic Innervation  Effectors in body wall are innervated by sympathetic fibers in spinal nerves  Effectors in head and thoracic cavity are innervated by fibers in sympathetic nerves  Effectors in abdominal cavity are innervated by sympathetic fibers in splanchnic nerves celiac, superior and inferior mesenteric ganglion celiac, superior and inferior mesenteric ganglion

14. 14 Adrenal Glands  Paired glands sit on superior pole of each kidney  Cortex (outer layer) secretes steroid hormones secretes steroid hormones  Medulla (inner core) a modified sympathetic ganglion a modified sympathetic ganglion stimulated by preganglionic sympathetic neuronsstimulated by preganglionic sympathetic neurons secretes neurotransmitters (hormones) into blood secretes neurotransmitters (hormones) into blood catecholamines (85% epinephrine and 15% norepinephrine)catecholamines (85% epinephrine and 15% norepinephrine)  Sympathoadrenal system is the closely related functioning adrenal medulla and symphathetic nervous system

15. 15 Parasympathetic Nervous System  Origin of preganglionic fibers pons and medulla (for cranial nerve nuclei) pons and medulla (for cranial nerve nuclei) sacral spinal cord segments S2-S4 sacral spinal cord segments S2-S4  Pathways of preganglionic fibers cranial nerves III, VII, IX and X cranial nerves III, VII, IX and X arising from sacral spinal cord arising from sacral spinal cord pelvic splanchnic nerves and inferior hypogastric plexuspelvic splanchnic nerves and inferior hypogastric plexus  Terminal ganglia in/near target organs long preganglionic, short postganglionic fibers long preganglionic, short postganglionic fibers

16. 16 Efferent Pathways

17. 17 Parasympathetic Cranial Nerves  Oculomotor nerve (III) narrows pupil and focuses lens  Facial nerve (VII) tear, nasal and salivary glands  Glossopharyngeal (IX) parotid salivary gland  Vagus nerve (X) viscera as far as proximal half of colon Cardiac, pulmonary, and esophageal plexus

18. 18 Enteric Nervous System  Nervous system of the digestive tract  Composed of 100 million neurons found in the walls of the digestive tract (no components in CNS)  Has its own reflex arcs  Regulates motility of viscera and secretion of digestive enzymes and acid in concert with the ANS

19. 19 Neurotransmitters and Receptors  Effects of ANS determined by types of neurotransmitters released and types of receptors on target cells determined by types of neurotransmitters released and types of receptors on target cells  Sympathetic has longer lasting effects neurotransmitters persist in synapse and some reach the bloodstream neurotransmitters persist in synapse and some reach the bloodstream  Many substances released as neurotransmitters enkephalin, substance P, neuropeptide Y, neurotensin, nitric oxide (NO) enkephalin, substance P, neuropeptide Y, neurotensin, nitric oxide (NO) NO inhibits muscle tone in BV walls (vasodilation)NO inhibits muscle tone in BV walls (vasodilation)

20. 20 Neurotransmitters and Receptors

21. 21 Cholinergic Receptors for ACh  Acetylcholine (Ach) binds to 2 classes of receptors 1. nicotinic receptors on all ANS postganglionic neurons, in the adrenal medulla, and at neuromuscular junctions (skeletal muscle)on all ANS postganglionic neurons, in the adrenal medulla, and at neuromuscular junctions (skeletal muscle) excitatory when ACh binding occursexcitatory when ACh binding occurs 2. muscarinic receptors on all gland, smooth muscle and cardiac muscle cells that receives cholinergic innervationon all gland, smooth muscle and cardiac muscle cells that receives cholinergic innervation excitatory or inhibitory due to subclasses of muscarinic receptorsexcitatory or inhibitory due to subclasses of muscarinic receptors

22. 22 Adrenergic Receptors for NE  Norepinephrine binds to 2 classes of receptors alpha adrenergic receptors (often excitatory) alpha adrenergic receptors (often excitatory) beta adrenergic receptors (often inhibitory) beta adrenergic receptors (often inhibitory)  Exceptions existence of subclasses of each receptor type existence of subclasses of each receptor type alpha 1 and 2; beta 1 and 2alpha 1 and 2; beta 1 and 2  Function by means of 2nd messengers cyclic AMP and alpha 1 receptors cyclic AMP and alpha 1 receptors

23. 23 Dual Innervation  Most of viscera receive nerve fibers from both parasympathetic and sympathetic divisions  Both divisions do not normally innervate an organ equally

24. 24 Dual Innervation  Antagonistic effects oppose each other oppose each other exerted through dual innervation of same effector exerted through dual innervation of same effector heart rate decreases (parasympathetic)heart rate decreases (parasympathetic) heart rate increases (sympathetic)heart rate increases (sympathetic) exerted because each division innervates different cells exerted because each division innervates different cells pupillary dilator muscle (sympathetic) dilates pupilpupillary dilator muscle (sympathetic) dilates pupil constrictor pupillae (parasympathetic) constricts pupilconstrictor pupillae (parasympathetic) constricts pupil

25. 25 Dual Innervation  Cooperative effects seen when 2 divisions act on different effectors to produce a unified effect parasympathetics increase salivary serous cell secretion parasympathetics increase salivary serous cell secretion sympathetics increase salivary mucous cell secretion sympathetics increase salivary mucous cell secretion

26. 26 Dual Innervation of the Iris

27. 27 Without Dual Innervation  Some effectors receive only sympathetic adrenal medulla, arrector pili muscles, sweat glands and many blood vessels adrenal medulla, arrector pili muscles, sweat glands and many blood vessels  Sympathetic tone a baseline firing frequency a baseline firing frequency vasomotor tone provides partial constriction vasomotor tone provides partial constriction increase in firing frequency = vasoconstrictionincrease in firing frequency = vasoconstriction decrease in firing frequency = vasodilationdecrease in firing frequency = vasodilation can shift blood flow from one organ to another as neededcan shift blood flow from one organ to another as needed sympathetic stimulation increases blood to skeletal and cardiac muscles -- reduced blood to skin sympathetic stimulation increases blood to skeletal and cardiac muscles -- reduced blood to skin

28. 28 Sympathetic and Vasomotor Tone Sympathetic division prioritizes blood vessels to skeletal muscles and heart in times of emergency. Blood vessels to skin vasoconstrict to minimize bleeding if injury occurs during stress or exercise.

29. 29 Control of Autonomic Function  ANS regulated by several levels of CNS cerebral cortex has an influence cerebral cortex has an influence hypothalamus (major visceral motor control center) hypothalamus (major visceral motor control center) nuclei for primitive functions – hunger, thirstnuclei for primitive functions – hunger, thirst midbrain, pons, and medulla oblongata midbrain, pons, and medulla oblongata nuclei for cardiac and vasomotor control, salivation, swallowing, sweating, bladder control, and pupillary changesnuclei for cardiac and vasomotor control, salivation, swallowing, sweating, bladder control, and pupillary changes spinal cord reflexes spinal cord reflexes defecation and micturition reflexes integrated in corddefecation and micturition reflexes integrated in cord brain can inhibit these responses consciouslybrain can inhibit these responses consciously

30. 30 Drugs  Sympathomimetics enhance sympathetic activity stimulate receptors or  norepinephrine release stimulate receptors or  norepinephrine release  Sympatholytics suppress sympathetic activity block receptors or inhibit norepinephrine release block receptors or inhibit norepinephrine release  Parasympathomimetics enhance activity while parasympatholytics suppress activity  Management of clinical depression Prozac blocks reuptake of serotonin to prolong its mood- elevating effect Prozac blocks reuptake of serotonin to prolong its mood- elevating effect MAO inhibitors interfere with breakdown of monoamine neurotransmitters MAO inhibitors interfere with breakdown of monoamine neurotransmitters  Caffeine competes with adenosine (inhibitory; causes sleepiness) by binding to its receptors