1. Materials and Methods Phase 1 Evaluated acute effects on fasting blood glucose and on post-oral glucose Groups 1 and 3 received distilled water Groups 2 and 4 received cinnamon extracts All groups fasted for 12 hours overnight and blood glucose levels were measured fasting and post-oral glucose load – This cycle was repeated 3 times to obtain mean blood glucose values

2. Cinnamon Extract Preparation Dosage for rats calculated according to body surface area Daily cinnamon dose for a 200g rat was 120mg in 1 ml of distilled water via a metal oro- gastric tube Dose(mg/kg)= Human dose (mg/kg) x [human factor/Rat factor]

3. Results No statistically significant difference in mean body weight and mean blood glucose levels at each hour of groups 1 and 2 Only the cinnamon administered group demonstrated a greater mean percentage difference at 0.5, 1 and 2 hour, but was still not statistically significant. Comparing groups 3 and 4 at 0.5 hour, group 4 demonstrated a faster decline in blood glucose.

4. Results Continued The mean percentage reduction in blood glucose from 0.5 to 1 hour in groups 3 and 4 were 7.7% and 27.7% respectively. The cinnamon group also demonstrated a lower blood glucose value at 8 and 12 hours post oral glucose load

5. Fasting and Post-oral glucose load levels.5, 8, and 12 hours were all statistically significant

6. Groups 1 and 2 Results There was no statistical difference between Groups 1 and 2 on fasting blood glucose

7. Groups 3 and 4 Results Group 3 (distilled water) declined slower than Group 4 (cinnamon extract)

8. Materials and Methods Phase II Evaluated the effects on food consumption, body weight, blood glucose, and lipids over 1 month 4 different groups: – Healthy rats Group A: 8 subjects, distilled water Group B: 8 subjects, cinnamon extracts – Diabetes induced rats Group C: 5 subjects, distilled water Group D: 5 subjects, cinnamon extracts

9. Diabetes Induction Groups C and D were induced with diabetes by a single intravenous injection of streptozotocin to the tail vein at a dose of 75 mg/kg body weight Tests were performed 14 days after injection to confirm and rats with a fasting blood glucose of >200mg/dl were allocated to Groups C and D

10. Results: Body weight and Food Consumption (Groups A & B) The mean weight of the control group increased significantly (Group A) in comparison with Group B. Mean food consumption of both Groups A and B had no significant difference between day 0 and day 30

11. Results: Body Weight and Food Consumption (Groups C & D) The weight reduction in both Groups C & D were not statistically significant Mean food consumption in Group D (cinnamon group) significantly reduced from day 0 to 30 Mean food consumption in Group C (distilled water) did not significantly reduce

12. Results: Mean Food Consumption Mean food consumption during study period (A) in healthy animals and (B) in diabetes induced

13. Results: Blood Glucose No statistical difference in healthy rats on fasting blood glucose levels and the 2 hour post-prandial blood glucose. In the diabetes induced animals, the fasting blood glucose was significantly lower in the cinnamon group on day 20 and 30. Also in the diabetes induced animals the 2 hours post-prandial blood glucose was significantly lower on day 30 in the cinnamon group

14. Results: Lipids In both healthy and diabetes induced animals, the cinnamon group showed significantly lower total in LDL cholesterol levels on day 30 compared to day 0. This difference was not observed in the control groups (Groups 1 & 3) HDL cholesterol and triglycerides remained unchanged in all 4 groups