1. Adhesion molecules and lymphocyte homing
成员：艾戈弋、鲍梦馨、车飞、陈超、董丽花、姜琳

2. review

3. Definition of adhesion molecules
Cell adhesion molecules (CAMs) are cell surface proteins involved in the interaction of cell-cell or cell-extracellular matrix.
CAMs take effect by the binding of receptor and ligand

4. Classification Integrin family Selectin family
Immunoglobulin (Ig) superfamily
Cadherin family
Mucin-like family
Other adhesion molecules

5. Integrins

6. Selectin

7. ISF

8. Cadherin

9. Lymphocyte homing
The directed migration of subsets of circulating lymphocytes into particular tissue sites.

10. Classification Lymphoid stem cell migrate to central lymphoid organs
Mature lymphocyte migrate to peripheral lymphoid organs
Recirculation of lymphocytes
Lymphocyte migrate to the sites of inflammation

12. How adhesion molecules participate in homing ?

13. Adhesion molecules mediate the process of homing
Lymphocyte homing receptor (LHR)
express on lymphocyte
Addressin
express on vascular endothelial cell

14. Adhesion Molecules on Lymphocyte

16. lymphocyte adhere, penetrate vascular endothelial cell

17. Adhesion molecules participate in lymphocyte homing
Lymphocyte homing receptor
Addressins
Adhesion molecules
Functions
L-selectin
Lymphocyte homing to peripheral immune organs
PNAd　
Addressin of peripheral high venous endothelial cell
CLA
Receptor on memory T cell surface for directionally homing to skin
E-selectin
Express on vascular endothelial cell of inflammation portion of skin
LFA-1
Participate in many lymphocytes for homing
ICAM-1
ICAM-2

18. Adhesion molecules participate in lymphocyte homing
Lymphocyte homing receptor
Addressins
Adhesion molecules
Functions
VLA-4
Receptor of lymphocyte homing
VCAM－1
Express on vascular endothelial cell of inflammation portion
CD44
Participate in many lymphocytes homing
MAd
Intestinal lymphatic tissue and lamina propria
integrin
Receptor of lymphocyte for directionally migrate to Peyre's Patch
MAd　
Addressin of vascular endothelial cell
α4β7

19. Adhesion molecules in normal condition in lymphocyte homing

20. Pro-T cell migrate to thymus
Homing receptor: CD44 and L-selectin expressed by pro-T cell
Adressin: EA1 molecule expressed by thymus vascular endothelial cell
And integrin α6β1、α6β4 play an important role in adhesion of pro-T cell

21. Lymphocyte migrate to peripheral lymphoid organs
Lymphocytes migrate to lymph node
Homing receptor: L-selectin on lymphocyte
Adressin：peripheral lymphonode vascular addressin (PNAd)
LFA-1/ICAM-1、ICAM-2 and CD44/Mad molecules participate in the adhesion and penetration

23. Lymphocyte migrate to peripheral lymphoid organs
Lymphocyte migrate to Peyer’s Patch
Homing receptor: integrin α4β7 molecule； CD44 and LFA-1 molecules
Adressin: Vascular endothelial cell of peyre’s patch specifically highly express mucosal vascular addressin (Mad); ICAM-1、ICAM-2
Peyre’s patch means the aggregated lymphoid nodule in small intestine.

24. Lymphocyte homing

25. Adhesion molecules in pathological condition (inflammation) in lymphocyte homing

27. Function of adhesion molecules in inflammation

28. Lymphocyte migrate to inflammation of skin
Homing receptor: cutaneous lymphocyte-associated antigen (CLA)；VLA-4；LFA-1
Adressin: E-selectin ；VCAM-1; ICAM-1/ICAM-2

29. Lymphocyte migrate to inflammation of skin

30. Lymphocyte migrate to inflammation of intestinal mucosa
Molecule expressed by lymphocyte of intestinal mucous tissue called mucosal lymphocyte antigen (MLA)

31. Lymphocyte migrate to inflammation of synovium
Homing receptor: LFA-1 ; VLA-4 ; CD44
Adressin: ICAM-1；VCAM-1；Mad

32. Disease Hyper-expressing adhesion molecules
Hypo-expressing adhesion molecules

33. more mechanism needed to be explored…
However…
more mechanism needed to be explored…

34. Thank you