1. ECML/PKDD-2005 Workshop on Discovery Challenge Guide to the Hepatitis Dataset Shusaku TsumotoShoji Hirano tsumoto@computer.org hirano@ieee.org Department of Medical Informatics, Faculty of Medicine, Shimane University, Japan

2. Hepatitis Dataset: Basic Information Donators Dr. Katsuhiko Takabayashi and Dr. Hideto Yokoi Department of Medical Informatics, Chiba University Hospital, Japan Subjects 771 patients of type B and C chronic virus hepatitis who took examinations at Chiba University Hospital during 1982 and 2001. Contents Biopsy information: dates and results stage of fibrosis, virus activity Period of applying interferon therapy Laboratory Examinations Blood tests (Biochemical, Hematological, DNA), Urinalysis Basic information of patients MID (masked ID), Sex, Date of Birth

3. Hepatitis Dataset: Structure 7 tables in CSV format An MID (masked ID) is used to relate information in different table Description of Examinations (459) Stationary data Temporal data MID In-hospital Exam Results (1,565,876) Out-hospital Exam Results (31,040) Basic Patient Information (771) Interferon Administration Information (198) Biopsy Information (961) *Added on July 4, 2003. Results of Hematological Analysis (42,914) *

4. Goals of the Challenge Evaluate whether the laboratory examinations can be used to estimate the stage of liver fibrosis. If possible, it can be used as an alternate of invasive biopsy. Discover the differences in temporal patterns between hepatitis B and C. Evaluate whether the interferon therapy is effective or not. High-cost therapy; but it is not effective for all patients. Can we forecast its effectiveness in advance using the results of laboratory examinations ? Validate the following hypothesis regarding GOT and GPT. (GOT or GPT) x (time) = (stage of liver fibrosis)