1. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings What knowledge should I bring to A&P course?  To name some:  Basic math – mean, fractions, percents, ratios, proportions, metric system, tables, graphs and charts  Basic chemistry – matter, elements, atomic structure, chemical interactions, bonds, chemical reactions, molecules/macromolecules,  Animal cell biology – membrane, organelles, cell cycle  Microscopy  Cell transport mechanisms – osmosis, diffusion and active transport  Enzymes  Scientific method and how to write lab report

2. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Overview of Anatomy and Physiology  Anatomy – the study of the structure of body parts and their relationships to one another  Gross or macroscopic – large visible body structures (heart, lungs, kidney etc.)  Different ways to approach gross anatomy:  Regional – study of all the structure in a particular region of the body (leg, abdomen etc.)  Systemic – study a particular system at a time.  Microscopic – deals with structures that are too small to be seen with the naked eye  Cytology – relates to the cells  Histology – study of the tissues  Physiology – the study of the function of the body

3. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Specialized Branches of Anatomy  Pathological anatomy – study of structural changes caused by disease  Radiographic anatomy – study of internal structures visualized by specialized scanning procedures such as X-ray, MRI, and CT scans  Molecular biology – study of anatomical structures at a subcellular level

4. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Necessary Life Functions  Maintaining boundaries – the internal environment remains distinct from the external environment  Cellular level – accomplished by plasma membranes  Organismal level – accomplished by the skin  Movement – locomotion, propulsion (peristalsis), and contractility  Responsiveness – ability to sense changes in the environment and respond to them  Digestion – breakdown of ingested foods  Metabolism – all the chemical reactions that occur in the body (we will study in details in A&P II)

5. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Necessary Life Functions  Excretion – removal of wastes from the body  Reproduction – cellular and organismal levels  Cellular – an original cell divides and produces two identical daughter cells  Organismal – sperm and egg unite to make a whole new person  Growth – increase in size of a body part or of the organism

6. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Systems covered in A&P I  Integumentary – cover, protection, sweat, receptors  Nervous system – control  Skeletal system – support, protection, calcium, blood cells, movement  Muscles - movement

7. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Systems covered in A&P II  Endocrine system – hormonal regulation  Cardiovascular system  Lymphatic system/immunity  Respiratory system  Digestive system  Urinary system  Reproductive system

8. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Survival Needs  Nutrients – needed for energy and cell building  Oxygen – necessary for metabolic reactions  Water – provides the necessary environment for chemical reactions (60-8% of body weight)  Normal body temperature – necessary for chemical reactions to occur at life-sustaining rates (why is it important to maintain core body temperature?)  Atmospheric pressure – required for proper breathing and gas exchange in the lungs

9. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Homeostasis  Homeostasis – ability to maintain a relatively stable internal environment in an ever-changing outside world  The internal environment of the body is in a dynamic state of equilibrium

10. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Some aspects of the internal environment that are homeostatically controlled  Temperature – normally 37 ° C (98.6° F)  pH – normally 7.35-7.45  Oxygen partial pressure – normally 95-105 mmHg at sea level  Carbon dioxide partial pressure – normally 35- 45 mmHg

11. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Homeostatic control  Homeostasis is a continuous process that uses physiological control system to monitor key functions  Some aspects of control systems:  Nervous system – coordinates and integrates conditions that are compatible with normal functions: blood volume, blood osmolarity, blood pressure, body temperature etc.  Tonic control – maintaining “moderate activity” – example – blood vessel diameter. Tonic control is not stopping or starting activity (similar to turning radio volume louder or softer)  Antagonistic control – for systems that are not under tonic control either by hormones or the nervous system (insulin and glucagon, sympathetic and parasympathetic)

12. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Local and long-distance control pathways  Local control – in the cell or tissue – autocrine or paracrine mechanisms (CO 2 levels in the tissue influence diameter of local capillaries)  Long distance control involves the nervous and endocrine systems.  The long distance control involves 3 components – sensor, integration center and effector

13. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Homeostatic Control Mechanisms  Variables produce a change in the body  The three interdependent components of control mechanisms:  Receptor – monitors the environments and responds to changes (stimuli)  Control center – determines the set point at which the variable is maintained  Effector – provides the means to respond to stimuli

14. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Negative Feedback  In negative feedback systems, the output shuts off the original stimulus

15. Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Positive Feedback  In positive feedback systems, the output enhances or exaggerates the original stimulus  Example: Regulation of blood clotting Figure 1.6