1. Viral Inhibition of the Anaphase- Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center Department of Biochemistry McGill University Montr é al, Canada

2. Viruses as tools in the study of cell transformation and apoptosis

6. Apoptin localizes in a transformation-dependent manner

8. Apoptin localization is regulated by a factor in transformed cells

9. Proteomic analysis of Apoptin-associated proteins

12. Subunit structure of the APC/C Thornton et al. Genes & Dev (2006)

13. Apoptin induces destabilization of the APC/C FPLC analysis

15. Apoptin colocalizes with APC/C within PML bodies

22. Tran et al. J Virol. 2007 Oct 17

23. Overview and future directions How does G2/M arrest proceed to apoptosis? Do current chemotherapies rely on APC/C inhibition for efficacy? Can the APC/C be an anti-cancer drug target?

24. Acknowledgements McGill University Isabelle Gamache Mohamed Mustafa Russell Towers Sarah Assadian Yiqing Lu Michael Hell U Mass Michael Green Destin Heilman Albert Parker Julie Zhou Reagents Frank Graham Crister Hoog