1. Team IMAC Integrative Medicine and Cancer Peter Frechette Stephanie Galanie Kevin Gu Anna Hung Sarah Kim Kelsey Merrick Krupa Nataraj Jessica Nooralian Mihir Patel Jessica Stevens Vivian Wang Albert Zhou Mentor: Dr. Mark Kantor

2. Introduction Cancer – a leading cause of death Complementary and Alternative Medicine (CAM) Many patients seek alternative treatments CAM is still largely unexplored http://www.fda.gov/consumer/updates/pics/doctor_patient.jpg

3. Literature Review The use of CAM Ingestible herbal supplements Reasons for CAM use search.ugent.be/libtiger/img/books.jpg

4. Objective To investigate the use and perceptions of herbal dietary supplements among a group of female breast cancer survivors and test the effects and safety of the most commonly used herbal dietary supplements.

5. Methodology (Mixed-Method Design) Questionnaire (descriptive, quantitative/qualitative) Laboratory work (experimental, quantitative) https://decs.nhgl.med.navy.mil/SURVEY/survey.gifhttp://www.chemlabs.bris.ac.uk/cetlpics/Outreac h/Chemnet_NAGTY06labbig.jpg

6. Survey Purpose To understand patients’ uses/perceptions of herbal dietary supplements Most commonly used Frequency Perceived efficacy/safety Reasons for use Sources of information

7. Questionnaire - Example

8. Sampling Frame Options George Washington University Medical Center Paper survey Georgetown University Paper survey BreastCancer.Net News Online survey http://www.gwu.edu/~resobgyn/circle.gif

9. Survey Analysis Frequency and statistical correlation Limitations Sampling error Response error Non-response error http://www.xycoon.com/images/freque1.jpg

10. Lab Work Dr. Tom Wang Agricultural Research Service; Diet, Genetics, and Immunology (USDA) Effects – Proliferation and Cell Cycle Dr. Tom Flynn Center for Food Safety and Applied Nutrition; Department of Toxicology (FDA) Safety – Liver Toxicity

11. Conclusion Objective Investigate the use and perceptions of herbal dietary supplements of female breast cancer survivors and test the effects and safety of the most commonly used herbal dietary supplements Publication in scholarly journal Contribution to literature http://infocusmagazine.org/5.1/images/hs _cam_standards.jpg

12. Timeline (I) Spring 2008 Thesis proposal Obtain IRB approval Develop and pilot survey Design laboratory experiments Create team website Fall 2008 Administer surveys Outline thesis Draft literature review for thesis Fall colloquia Begin lab research Spring 2009 Finish survey data collection Organize survey data Draft chapters 1, 2, and 3 of thesis Undergraduate Research Day Continue lab research

13. Timeline (II) Fall 2009 Complete survey data analysis Draft chapters 4 and 5 Draft presentation for thesis conference Five experts for conference panel Finish lab data collection and analysis Spring 2010 Submit final team information Finish thesis Thesis conference Submit final thesis for publication

14. Budget Surveying costs Online advertisement or printing Statistician consultation fees Laboratory costs Supplements Cell line media Future conferences www.rig.netfirms.com

15. Acknowledgements Dr. Kantor, Team Mentor Dr. Tom Wang Dr. Tom Flynn Dr. Gordon Willis Dr. James Wallace Dr. Rebecca Thomas Courtenay Barrett

16. Thank You. Questions?