1. Breakout Group C Jennifer Seed (Chairwoman), Allison Jenkins (Rapporteur ), Janet Kester, Daniele Staskal, Gulan Sun, Valerie Meyers (phone), Andy Maier (phone), Bob Budinsky (phone), Ted Simon (phone)

2. Case Study Proposal #8 Exploring three conceptual models for individual/population dose response using 2,3,7,8-trachlorodibenzodioxin (TCDD) as an example. TCDD is data-rich and would permit exploration of all three models. Ted Simon, Bob Budinsky, J. Craig Rowlands Very well described, draft proposal completed Existing publication (Simon 2009) and Simon et al. (unpublished)

3. Case Study Proposal #20 #20 – Three nuclear receptors, AHR, CAR/PXR and PPARα, will be used as examples for how their biology can be used to define mode of action and dose-response for liver tumors in rodents. Teams are in the process of developing case studies for September 2010 Nuclear Receptor Workshop Breakout Group C proposes to link case study proposals #20 (general) and #8 (specific example) #20 (or similar) will be prepared for September 2010 Nuclear Receptor Workshop.

4. Case Study Proposals #6, #25 Screening proposals Easily Accomplished Recommend problem formulations are expanded in both case study proposals

5. Case Study Proposal #15 Ongoing chromium MOA study to address data gaps in the knowledge of its mode of action. Data will not be completed by date of 2 nd ARA Workshop Breakout Group C proposes to ‘table’ Proposal #15 for consideration at ARA Workshop 2

6. Idea for Case Study DNA damage by intracellularly generated formaldehyde has been proposed as a carcinogenic mode of action for several chemicals (e.g., methanol, MTBE). Data on formaldehyde-DNA adduct formation can be used to evaluate this hypothesis. Unknown if sufficient data exist. Janet Kester is contact person.