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Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes by Joseph C. Mudd, Patrick Murphy, Maura Manion, Robert Debernardo,

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Presentation on theme: "Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes by Joseph C. Mudd, Patrick Murphy, Maura Manion, Robert Debernardo,"— Presentation transcript:

1 Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes by Joseph C. Mudd, Patrick Murphy, Maura Manion, Robert Debernardo, Jeffrey Hardacre, John Ammori, Gareth A. Hardy, Clifford V. Harding, Ganapati H. Mahabaleshwar, Mukesh K. Jain, Jeffrey M. Jacobson, Ari D. Brooks, Sharon Lewis, Timothy W. Schacker, Jodi Anderson, Elias K. Haddad, Rafael A. Cubas, Benigno Rodriguez, Scott F. Sieg, and Michael M. Lederman Blood Volume 121(15):2914-2922 April 11, 2013 ©2013 by American Society of Hematology

2 Monitoring S1P1 activity in human T-cells. Joseph C. Mudd et al. Blood 2013;121:2914-2922 ©2013 by American Society of Hematology

3 Blunted responses to S1P in the HIV-1+ lymph node. Joseph C. Mudd et al. Blood 2013;121:2914-2922 ©2013 by American Society of Hematology

4 CD69 expression and impaired T-cell responsiveness to S1P. Joseph C. Mudd et al. Blood 2013;121:2914-2922 ©2013 by American Society of Hematology

5 Induction of CD69 and inhibition of S1P responses in human T cells in vitro. Joseph C. Mudd et al. Blood 2013;121:2914-2922 ©2013 by American Society of Hematology

6 Diminished levels of S1P1 and KLF2 RNAs in HIV-1 + LNs. (A) S1P1 and (B) KLF2 gene expression in LN tissues was assessed by real-time PCR and normalized to levels of 18S rRNA. Joseph C. Mudd et al. Blood 2013;121:2914-2922 ©2013 by American Society of Hematology

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