1. The Cell Cycle & Mitosis Chapter 5

2. 5.1 – The Cell Cycle Key Concept: – Cells have distinct phases of growth, reproduction, and normal functions.

3. The cell cycle has 4 main stages. The cell cycle is a regular pattern of growth, DNA replication, and cell division.

4. The main stages of the cell cycle are Gap 1, Synthesis, Gap 2, & Mitosis. Gap 1 (G1): cell growth and normal functions, copy organelles Synthesis (S): copies DNA Gap 2 (G2): additional growth Mitosis (M): includes division of the cell nucleus (mitosis) and division of the cell cytoplasm (cytokinesis) – Mitosis occurs only if the cell is large enough and the DNA undamaged.

5. 1 11 10 9 5 4 3 6 8 7 15 12 13 2 14

6. Cells divide at different rates. The rate of cell division varies with the need for that type of cell. Some cells are unlikely to divide (in Gap 0/G0 of the cell cycle) – Example: neurons

7. Cell size is limited. Volume increases faster than surface area. – Cells need to stay small to allow diffusion and osmosis to work efficiently.

8. Surface area must allow for adequate exchange of materials. – Cell growth is coordinated with division. – Cells that must be large have unique shapes.

9. 5.2 – Mitosis & Cytokinesis Key Concept: – Cells divide during mitosis and cytokinesis.

10. Chromosomes condense at the start of mitosis. DNA wraps around proteins (histones) that condense it.

11. DNA plus proteins is called chromatin. One half of a duplicated chromosome is a chromatid. Sister chromatids are held together at the centromere. Telomeres protect DNA and do not include genes.

12. Mitosis and cytokinesis produce two genetically identical daughter cells. Interphase prepares the cell to divide. During interphase, the DNA is duplicated. Box 1: Interphase

13. Mitosis divides the cell’s nucleus in four phases. Prophase (Box 2) – Chromosomes condense, spindle fibers form, and the nuclear membrane disappears

14. Mitosis divides the cell’s nucleus in four phases. Metaphase (Box 3) – Chromosomes line up in the middle of the cell

15. Mitosis divides the cell’s nucleus in four phases. Anaphase (Box 4) – Sister chromatids are pulled apart to opposite sides of the cell

16. Mitosis divides the cell’s nucleus in four phases. Telophase (Box 5) – Two nuclei form at opposite ends of the cell, the nuclear membranes reform, and the chromosomes uncoil back into chromatin

17. Cytokinesis differs in animal and plant cells. Cytoplasm separates – Animal cells: membrane pinches the two new cells apart – Plant cells: a cell plate (new cell wall) separates the two new cells

18. 5.3 – Regulation of the Cell Cycle Key Concept: – Cell cycle regulation is necessary for healthy growth.

19. Internal and external factors regulate cell division. External Factors Include physical and chemical signals – Cell to cell contact: when one cell touches another, they stop growing – Growth factors: chemical signals released by cells that tell other cells to grow Trigger internal factors, which affect the cell cycle Internal Factors Kinases and cyclins – Kinases: enzymes in cells, some of which help control the cell cycle – those that do are activated by cyclins – Cyclins: proteins that are made and destroyed during the cell cycle; activate kinases Both help to advance a cell to different parts of the cell cycle

20. Cell division is uncontrolled in cancer. Cancer cells form disorganized clumps called tumors. – Benign tumors remain clustered and can be removed. – Malignant tumors metastasize, or break away, and can form more tumors.

21. Apoptosis is programmed cell death. Some cells need to grow and divide but other cells need to die. Apoptosis is the process of programmed cell death. – Normal feature in healthy organisms – Caused by a cell’s production of self-destructive enzymes – Occurs during fetal development (responsible for separation of fingers and toes)

22. Cancer cells do not carry out normal cell functions. Cancer cells come from normal cells with damage to genes involved in cell-cycle regulation. Carcinogens are substances known to cause cancer (they damage those genes) – Chemicals, tobacco smoke, X-rays, UV rays Standard cancer treatments typically kill both cancerous and normal, healthy cells.

23. 5.4 – Asexual Reproduction Key Concept: – Many organisms reproduce by cell division.

24. Binary fission is similar to mitosis. Asexual reproduction is the creation of offspring from a single parent. – Binary fission produces two daughter cells genetically identical to the parent cells. – Binary fission occurs in prokaryotes.

25. Environment determines which form of reproduction is most advantageous Asexual reproduction is an advantage in consistently favorable conditions. Sexual reproduction is an advantage in changing conditions.

26. Some eukaryotes reproduce by mitosis. Budding forms a new organism from a small projection growing on the surface of the parent. Fragmentation is the splitting of the parent into pieces that each grow into a new organism. Vegetative reproduction forms a new plant from the modification of a stem or underground structure on the parent plant.

27. 5.5 – Multicellular Life Key Concept: – Cells work together to carry out complex functions.

28. Multicellular organisms depend on interactions among different cell types. Tissues are groups of cells that perform a similar function. Organs are groups of tissues that perform a specific or related function. Organ systems are groups of organs that carry out similar functions.

29. Specialized cells perform specific functions. Cells develop into their mature forms through the process of cell differentiation. Cells differ because different combinations of genes are expressed. A cell’s location in an embryo helps determine how it will differentiate.