1. Amnesia HM - 1953 (27 y/o) Bilateral medial temporal lobe damage

4. Assessment of Memory Digit span + 1 - HM poor (8 - tops) Block tapping - HM poor ( 5 taps) Mirror Drawing - motor learning HM fine Rotary Pursuit - motor learning Incomplete pictures Operant conditioning

10. Why two types? Flexibility

11. Memento

13. Amnesia & Dementia Korsakoff’s Syndrome - chronic alcoholism - thiamine (B1) - medial diencephalon damage Alzheimer’s Disease - diffuse damage - Ach in medial forebrain? Concussion Posttraumatic memory loss - retrograde & anterograde - temporary - electroconvulsive shock therapy - similar - interfere with consolidation

15. Hebb Rule: if a synapse is repeatedly active at the same time that the post synaptic neuron fires, the synapse will be strengethened. Hebb Synapse: a synapse that increases in effectiveness because of simultaneous activity in the presynaptic and postsynaptic neurons. NMDA receptor - Glutamate

17. Inferior temporal (perirhinal) lesions disrupt this

18. Hippocampus lesions disrupt this

21. Delayed Non-matching-to-sample - frontal lobe lesions disrupt Frontal lobe important for remembering the task demands

25. object space

27. The general arrangement of the pool.

28. In a place-learning task, a rat is put into the pool at various starting locations. The animal must learn the location of a hidden platform, which can be done only by considering the configuration of visual cues in the room-windows, wall decoration, potted plants, and the like.

29. In a matching-to-place task, the rat is again put in the pool at random locations, but in this case the hidden platforms is in a new location each test day. The animal must learn that the location where it finds the platform on the first trial of each day is the location of the platform for all that day’s trials.

30. In a landmark-learning task, the rat is required to ignore the room cues and to learn that the cue on the wall of the pool signals the location of the platform.