1. What do these words mean?

2. 2 Organic Compounds CompoundsCARBON organicCompounds that contain CARBON are called organic. Macromoleculesorganic moleculesMacromolecules are large organic molecules. copyright cmassengale

3. 3 Carbon (C) Carbon4 electronsCarbon has 4 electrons in outer shell. Carboncovalent bonds 4Carbon can form covalent bonds with as many as 4 other atoms (elements). C, H, O or NUsually with C, H, O or N. Example: CH4 (Methane)Example: CH4 (Methane) copyright cmassengale

4. Next Word…..

5. Polygons Polygamy Polyester

6. What does “Mono” mean?

7. A Polymer Here are some analogies to better understand what polymers and monomers are…. EXAMPLE of POLYMER MONOMER A TRAIN? A NECKLACE? If the train is the whole polymer, what would be the small groups that make up the train? If the necklace is the polymer, what are the monomers that make up the necklace?

8. A Polymer Here are some analogies to better understand what polymers and monomers are…. EXAMPLE of POLYMER MONOMER A TRAINTHE CARS A NECKLACEEACH PEARL If the train is the whole polymer, what would be the small groups that make up the train? If the necklace is the polymer, what are the monomers that make up the necklace?

9. Now you and a buddy need to think of at least 2 other analogies for a polymer and its monomers.

10. 10 Question: How Are Macromolecules Formed? copyright cmassengale

11. 11 Answer: Dehydration Synthesis “condensation reaction”Also called “condensation reaction” polymers monomers“removing water”Forms polymers by combining monomers by “removing water”. HOH HH H2OH2O copyright cmassengale

12. 12 Question: How are Macromolecules separated or digested? copyright cmassengale

13. 13 Answer: Hydrolysis monomers“adding water”Separates monomers by “adding water” HO HH H H2OH2O copyright cmassengale

14. Look at the label to the left. 3 of the 4 macromolecules can be found in foods. The 3 biochemical molecules found on a nutrition label are: 1____________________ 2____________________ 3____________________ (0 grams in this product) (13 grams in this product) (9 grams in this product)

15. LET’S BEGIN WITH CARBOHYDRATES They are the main source for the body to gain energy. They are our fuel! They make up the cell wall in plants which allow them to grow tall, without this carbohydrate, a plant would be a mushy mess! This type of carbohydrate is called Cellulose. THINK: CARBS= ENERGY and CELL WALLS

16. CARBOHYDRATES Each carbohydrate is made up of… THINK: “CHO”

17. CARBOHYDRATES THERE ARE 2 TYPES OF CARBOHYDRATES Simple Complex

18. Simple Sugars are carbohydrates made up of 1 or 2 monomers. They also taste sweet.

19. CARBOHYDRATES Carbohydrates are chains (polymers) made of monomers. The most common monomer of carbohydrates is…

20. The shape of Glucose is a hexagonal ring

21. 21 Carbohydrates Monosaccharide: one sugar unit Examples:glucose ( Examples:glucose (C 6 H 12 O 6 )deoxyriboseriboseFructoseGalactose glucose copyright cmassengale

22. Simple Sugars

23. 23 Carbohydrates Disaccharide: two sugar unit Examples: –Sucrose (glucose+fructose) –Lactose (glucose+galactose) –Maltose (glucose+glucose) glucoseglucose copyright cmassengale

24. Complex Carbohydrates… What are they? Complex Cabohydrates are polymers made up of many monomers. Most also taste starchy.

25. 25 Carbohydrates Polysaccharide: many sugar units Examples:starch (bread, potatoes) glycogen (beef muscle) cellulose (lettuce, corn) glucoseglucose glucoseglucose glucoseglucose glucoseglucose cellulose copyright cmassengale

26. Complex Carbohydrates

27. NOW ONTO PROTEINS They are the major structural molecules in living things for growth and repair : muscles, ligaments, tendons, bones, hair, skin, nails…IN FACT ALL CELL MEMBRANES have protein in them They make up antibodies in the immune system They make up enzymes for helping chemical reactions They makeup non-steriod hormones which THINK: Proteins= membranes, enzymes, antibodies, non- steriod hormones, structural molecules, “MEANS”

28. 28 Proteins (Polypeptides) peptide bonds polypeptidesAmino acids (20 different kinds of aa) bonded together by peptide bonds (polypeptides). Six functions of proteins:Six functions of proteins: 1.Storage:albumin (egg white) 2.Transport: hemoglobin 3.Regulatory:hormones 4.Movement:muscles 5.Structural:membranes, hair, nails 6.Enzymes:cellular reactions copyright cmassengale

29. Microscope View of Skin and Nails This is skinThis is a nail

30. PROTEINS Proteins are made of long chains (polymers) made of monomers. All proteins are made of the monomer…

31. http://www.hcc.mnscu.edu/programs/dept/chem/V.27/amino_acid_structure_2.jpg

32. http://upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Amino_acids_2.png/483px-Amino_acids_2.png

33. PROTEINS Each protein is made up of… THINK: “CHONS”

34. 34 Proteins (Polypeptides) Four levels of protein structure: A.Primary Structure B.Secondary Structure C.Tertiary Structure D.Quaternary Structure copyright cmassengale

35. 35 Primary Structure peptide bonds (straight chains) Amino acids bonded together by peptide bonds (straight chains) aa1aa2aa3aa4aa5aa6 Peptide Bonds Amino Acids (aa) copyright cmassengale

36. 36 Secondary Structure primary structurecoilspleats hydrogen bonds3-dimensional folding arrangement of a primary structure into coils and pleats held together by hydrogen bonds. Two examples:Two examples: Alpha Helix Beta Pleated Sheet Hydrogen Bonds copyright cmassengale

37. 37 Tertiary Structure Secondary structuresbentfolded more complex 3-D arrangementSecondary structures bent and folded into a more complex 3-D arrangement of linked polypeptides Bonds: H-bonds, ionic, disulfide bridges (S-S)Bonds: H-bonds, ionic, disulfide bridges (S-S) “subunit”.Call a “subunit”. Alpha Helix Beta Pleated Sheet copyright cmassengale

38. 38 Quaternary Structure Composed of 2 or more “subunits” Globular in shape Form in Aqueous environments enzymes (hemoglobin)Example: enzymes (hemoglobin) subunits copyright cmassengale

39. LIPIDS ARE NEXT They are a great source of STORED ENERGY so we have it in the future. They INSULATE the body to maintain normal body temperature and they CUSHION the internal organs for protection. They produce hormones for the body called STERIODS They waterproof surfaces of animals,plants, and fruits- these are waxes! THINK: Waterproof, insulate, steriods, energy, cushion… “WISE C”

40. LIPIDS Each carbohydrate is made up of… THINK: “CHO”

41. OH NO CHO! Lipids like Carbs? You might have noticed that both carbohydrates and lipids have the elements Carbon, Hydrogen, and Oxygen. “CHO” A carbohydrate, has twice as many hydrogen atoms as the number of oxygen atoms. EX: C 6 H 12 O 6 (This is a carb= there are double the number of H compared to O) On the other hand, lipids have a lot more than twice the amount hydrogen atoms as the number of oxygen atoms. EX: C 27 H 46 O cholesterol

42. 42Lipids not soluble in waterGeneral term for compounds which are not soluble in water. are soluble in hydrophobic solventsLipids are soluble in hydrophobic solvents. Remember:“stores the most energy”Remember: “stores the most energy” Examples:1. FatsExamples:1. Fats 2. Phospholipids 3. Oils 4. Waxes 5. Steroid hormones 6. Triglycerides copyright cmassengale

43. 43 Lipids Six functions of lipids: 1.Long term energy storage 2.Protection against heat loss (insulation) 3.Protection against physical shock 4.Protection against water loss 5.Chemical messengers (hormones) 6.Major component of membranes (phospholipids) copyright cmassengale

44. LIPIDS Lipids are chains (polymers) made of monomers. The most common monomer of lipids is…

45. 45 Lipids Triglycerides: c1 glycerol3 fatty acids Triglycerides: composed of 1 glycerol and 3 fatty acids. H H-C----O H glycerol O C-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 3 = fatty acids O C-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 3 = O C-CH 2 -CH 2 -CH 2 -CH =CH-CH 2 -CH 2 -CH 2 -CH 2 -CH 3 = copyright cmassengale

46. The Shape of a triglyceride is like the letter E This is a triglyceride molecule

47. 47 Fatty Acids fatty acids There are two kinds of fatty acids you may see these on food labels: 1.Saturated fatty acids: no double bonds (bad) 2.Unsaturated fatty acids: double bonds (good) O C-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 3 = saturated O C-CH 2 -CH 2 -CH 2 -CH =CH-CH 2 -CH 2 -CH 2 -CH 2 - CH 3 = unsaturated copyright cmassengale

48. Saturated Fatty Acids have no double bonds and are saturated with hydrogen. Unsaturated Fatty Acids have double bonds. www.agen.ufl.edu/~chyn/age2062/lect/lect_02/3_16.gif

49. Cis and Trans Fatty Acids http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/cis_trans.gif

50. Cis –vs-Trans Shapes http://www.mansfield.ohio-state.edu/~sabedon/047cis.gif

51. LIPIDS…Some interesting info There are many different types of steroids. They are all lipids. Their functions vary. Some common steroids are: SEX STEROIDS ANABOLIC STERIODS CHOLESTEROL Like testosterone and estrogen They increase muscle

52. LIPIPS…Some interesting info Some anabolic steroids are illegal And can be dangerous and very unhealthy NATURAL STERIODS IN OUR BODY INCREASE MUSCLE GROWTH AND BONE DEVELOPMENT AND ARE GOOD. THE ILLEGAL ONES THAT ARE SYNTHETIC ARE BAD.

53. NUCLEIC ACIDS THERE ARE 2 TYPES OF NUCLEIC ACIDS DNA RNA

54. Nucleic Acids 1)DNA Is our genetic material. Chromosomes are made of DNA. Chromosomes contain the “recipes” to make proteins for your body. 2)RNA Reads the DNA “protein recipes” and makes the proteins for your body.

55. Nucleic Acids Each nucleic acid is made up of… THINK: “PONCH”

56. NUCLEIC ACIDS

57. 57 Nucleic acids Two types:Two types: a. Deoxyribonucleic acid (DNA- double helix) b. Ribonucleic acid (RNA-single strand) b. Ribonucleic acid (RNA-single strand) Nucleic acids nucleotides dehydration synthesisNucleic acids are composed of long chains of nucleotides linked by dehydration synthesis. copyright cmassengale

58. 58 Nucleic acids Nucleotides include:Nucleotides include: phosphate group pentose sugar (5-carbon) nitrogenous bases: adenine (A) thymine (T) DNA only uracil (U) RNA only cytosine (C) Guanine (G) Guanine (G) copyright cmassengale

59. 59 Nucleotide O O=P-O OPhosphate Group Group N Nitrogenous base (A, G, C, or T) (A, G, C, or T) CH2 O C1C1 C4C4 C3C3 C2C2 5 Sugar Sugar(deoxyribose) copyright cmassengale

60. 60 DNA - double helix P P P O O O 1 2 3 4 5 5 3 3 5 P P P O O O 1 2 3 4 5 5 3 5 3 G C TA copyright cmassengale

61. The shape of a nucleic acid is:

62. ENERGY Energy that is gained by consuming food is called a

63. ENERGY Three of the BIG 4 provide us with energy through the food we eat: BIG 4 MACROMOLECULES Number of Calories it provides Carbohydrates Proteins Lipids Nucleic Acids

64. ENERGY So… BIG 4 MACROMOLECULES Number of Calories it provides Carbohydrates4 Proteins4 Lipids9 Nucleic Acids0 TEST: TEST: Are you smart? If you eat a sandwhich with 46 grams of carbs and 24 grams of protein and 10 grams of fat, how much energy will you gain?

65. Which one of the following molecules is a lipid? A carbohydrate? 1.) C 27 H 46 O 2.) C 12 H 24 O 12 Lipid Carbohydrate

66. What kind of carbohydrate gives you a quick burst of energy? What kind of carbohydrate gives you long term energy? You are stranded on a desert island and have found a box of food. Considering you have almost nothing to eat on the island, which of the following would be the best food to have in the box? WHY? –Crackers –Butter –Steak How many Calories are found in 1 gram of protein? How many Calories are in 1 gram of nucleic acid?

67. Final Review Questions Please do not look back at the information in your handout until you have answered all of the following questions. 1. What are 2 examples of simple sugars and 2 examples of complex carbohydrates not mentioned already? 2. What is a polymer? 3. What is a monomer? 4. Carbohydrates are the body’s main source of ________________. 5. Define in your own words: Biochemical Macromolecule 6. Proteins are major structural molecules in living things. List 5 places or things in your body that contain a lot of protein. 7. What are enzymes? What are they made of? 8. What are hormones? 9. What does your thyroid hormone do? 10. Name three types of proteins. 11. What are the functions of lipids? 12. What elements are found in each of the Big 4 molecules? 13. What does DNA do? RNA? 14. How many Calories are found in 1 gram of each of the Big 4 molecules? 15. What are 5 possible effects of illegal steroid use? 16. What are 3 functions of lipids? 17. What is the function of waxes? 18. What are 2 ways simple sugars are different from complex carbohydrates? 19. What are 4 organic macromolecules?