1. Chapter 10 Lecture Mark D. Herbst, M.D., Ph.D.

2. Image Detail and Noise Two image characteristics that reduce the visibility of anatomy/pathology –Blurring – level of detail – related to pixel size –Visual Noise – random bright and dark dots These two are related, because if you improve one, you worsen the other.

3. Other image characteristics also impact visibility of anatomy/pathology Camouflage Irregular borders Low contrast Motion (blurring)

4. How detailed must the image be? The goal is to select the optimal voxel size for the anatomy and pathology you want to see

5. What is the MR image? Really just a display of the signal intensities from the voxels in the patient as pixels. No detail is seen within a voxel (pixel).

6. Voxels, FOV, and Matrix size Pixel size = FOV / matrix size Voxel size = pixel size x slice thickness FOV = field of view – can be square or rectangular (i.e., 25 cm x 25 cm, or 25 cm x 20 cm) Matrix = how many pixels in the image, square or rectangular (i.e., 256 x 256, or 256 x 192)

7. Exercise What is the voxel size? –FOV = 25 cm, Matrix = 256 x 256, ST = 1 mm –FOV = 13 cm, Matrix = 256 x 128, ST = 1 mm –FOV = 50 cm x 25 cm, Matrix = 512 x 256, ST = 5 mm

8. Sources of Noise The patient’s body Electrical devices – radio, TV, lights, motors, etc.

9. Signal-to-Noise Ratio(S/N) Two ways to increase S/N –Increase signal –Decrease noise

10. How to increase S/N Increase voxel size—this increases S –Done by increasing ST or increasing pixel size Increase field strength –increases S because S increases with increasing B 0 –Also increases N, but not as much as S, so S/N increases

11. How to increase S/N Adjust TR and TE – longer TR and shorter TE lead to increase S, and therefore, increased S/N Use better RF receive coils –Body coils are worst, small surface coils are best –New multicoil designs increase S

12. How to increase S/N Decrease receive Bandwidth (BW) BW = 1/(dwell time) Problem of increased chem shift artifact with decreased BW If you increase BW to decrease chem shift, you get more noise

13. How to increase S/N Signal averaging The number of signals averaged (NSA), or the number of excitations (NEX) or the number of acquisitions (NACQ) all mean the same thing. It is like taking multiple pictures and adding them together. The noise does not increase as much as the signal. S/N ~ sqrt (NEX), so 4 NEX doubles S/N