1. Taylor Miller Marine Anti-Cancer Compounds

3. What’s the deal?

4. Compound (figure number) Source organismChemical classMolecular targetCurrent status Ecteinascidin 743Ecteinascidia turbinate (tunicate; possible bacterial source) Tetrahydroisoquinolone alkaloid TubulinPhase II Dolastatin 10Dolabella auricularia/Symploca sp. (mollusc/cyanobacteriu m) Linear peptideTubulinPhase II Bryostatin 1Bugula neritina (bryozoan) Macrocyclic lactonePKCPhase II SynthadotinDolabella auricularia/Symploca sp. (synthetic analogue) Linear peptideTubulinPhase II Kahalalide FElysia rufescens/Bryopsis sp. (mollusc/green alga) Cyclic depsipeptideLysosomes/erbB pathway Phase II