1. Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington Sea urchin larvae

2. Grand Challenge IV Understanding how genomes produce organisms Generation of organismal diversity Heliconius

3. Grand Challenge IV Understanding how genomes produce organisms Generation of organismal diversity Geospiza

4. Grand Challenge IV Understanding how genomes produce organisms Environmental influences on growth Arabidopsis

5. The challenges in developmental biology Generation of cellular diversity Generation of shape: morphogenesis Growth, repair, regeneration Drosophila

6. The challenges in developmental biology Generation of cellular diversity Generation of shape: morphogenesis Growth, repair, regeneration Carollia

7. The challenges in developmental biology Generation of cellular diversity Generation of shape: morphogenesis Growth, repair, regeneration Cnemidophorus

8. Progress at the interface Convergence of genetics and development – Defining components Integration of Cell Biology – Cell shape to tissue architecture Systems biology – the future? – Moving beyond the descriptive

9. Systematic analysis of development Gene regulatory networks

10. Systematic analysis of development In toto imaging Kane and Karlstrom, 1995

11. Systematic analysis of development In toto imaging – xyzgt http://www.embl.de/digitalembryo/

12. Moving forward Instrumentation – ways to measure Centralized databases (GCOB #11) – Access, analyze, manipulate large data sets – Standardization New model organisms – Genomes – Genetics – Lab culture – Transgenics Quantitative training

13. Moving forward Distribution of effort Centralized resources Distribution of data Recognition