1. Data from the Collaborative HIV Paediatric Study (CHIPS) Reports up to March 2006* *Numbers are based on reports received rather than children seen to the end of March 2006. 2005 data are subject to reporting delay and may therefore be incomplete.

2. Background for CHIPS The Collaborative HIV Paediatric Study (CHIPS) was established in April 2000 as a multi-centre cohort study of HIV infected children in the UK and Ireland. The collaboration is between 39 centres in the UK and Ireland that care for HIV-infected children, many of whom are enrolled in PENTA trials the National Study of HIV in Pregnancy and Childhood (NSHPC), and the MRC Clinical Trials Unit

3. Follow-up status of 1164 children enrolled in CHIPS

4. Age and year at first presentation to medical services in the UK and Ireland (N=1164) Up to 2002 2003 2004 2005 Total At birth 101 (11%) 9 (7%) 7 (7%) 2 (4%) 119 (10%) <1 yr 242 (28%) 14 (11%) 14 (15%) 7 (12%) 277 (24%) 1-4 yrs 304 (35%) 32 (24%) 26 (27%) 11 (19%) 373 (32%) 5-9 yrs 162 (18%) 52 (39%) 29 (31%) 19 (33%) 262 (23%) >=10 yrs 70 (8%) 26 (20%) 19 (20%) 18 (32%) 133 (11%) Total 879 (100%) 133 (100%) 95 (100%) 57 (100%) 1164 (100%) *Includes all children (those still in follow-up and those who have died, lost to follow-up, left the UK & Ireland or transferred to adult care)

5. Year No in Median age -------------------- Age groups ---------------- follow-up (IQR)  1 yr 2-4 yrs 5-9 yrs 10-14 yrs  15 yrs 1996 347 5.2 (2.8-7.6) 23(7%) 143(41%) 142(41%) 39(11%) 0(0%) 1997 398 5.6 (3.1-8.2) 27(7%) 145(36%) 169(42%) 54(14%) 3(1%) 1998 468 6.1 (3.3-8.9) 21(4%) 160(34%) 202(43% 76(16%) 9(2%) 1999 526 6.7 (3.9-9.9) 21(4%) 160(30%) 219(42%) 110(21%) 16(3%) 2000 611 7.3 (4.1-10.6) 19(3%) 175(29%) 240(39%) 140(23%) 37(6%) 2001 692 8 (4.8-11.2) 15(2%) 175(25%) 266(38%) 191(28%) 45(7%) 2002 778 8.3 (5.2-11.8) 19(2%) 164(21%) 307(39%) 225(29%) 63(8%) 2003 890 8.7 (5.8-12.2) 19(2%) 162(18% 343(39%) 283(32%) 83(9%) 2004 948 9.3 (6.3-12.7) 15(2%) 155(16%) 354(37%) 317(33%) 107(11%) 2005 941 9.5 (6.5-12.7) 13(1%) 132(14%) 360(38%) 329(35%) 107(11%) Age distribution of children in follow-up over calendar time * Age is taken to be age at start of the year, or age at presentation if child presented during that year

6. All hospital admissions during 2000-2004 Year Number Number Proportion Total Rate children children admitted number (# adm seen admitted (%) admissions per pyar) 2000 582 164 28 325 0.60 2001 639 171 27 301 0.51 2002 695 153 22 239 0.37 2003 789 170 22 299 0.42 2004 865 163 19 260 0.34 Retrospective data on admissions not collected for children from centres joining since Aug 2003. These children are counted from when they begin prospective follow-up in CHIPS. Admissions may be underreported for children in shared care where only information from the main CHIPS follow-up centre are reported. Data for 2005 are incomplete and are not presented.

7. HIV RNA viral load at 6 months after starting HAART as first line therapy N=547 with measurements available (124 missing) Year HIV RNA (copies/ml) 400 Total -1999 32 (20%) 58 (36%) 72 (44%) 162 (100%) 2000/01 37 (32%) 30 (26%) 47 (41%) 114 (100%) 2002/03 64 (41%) 57 (37%) 35 (22%) 156 (100%) 2004- 65 (57%) 31 (27%) 19 (17%) 115 (100%) Total 198 (36%) 176 (32%) 173 (32%) 547 (100%) *Includes all children (those still in follow-up and those who have died, lost to follow-up, left the UK & Ireland or transferred to adult care)

8. Data on 954 children who are still alive and in follow-up (941 in CHIPS centres and 13 who have transferred to non-CHIPS centres) Those who have died, lost to follow-up, left the UK & Ireland or transferred to adult care are excluded

9. Demographic Data (N=954) (Data provided by NSHPC) - 480(50%) are female - 498(52%) born UK/Ireland, 448(47%) born abroad (place of birth not known for 8 children) - Ethnicity White 94 (10%) Black African 712 (75%) Black Other 13 (1%) Indian SC 13 (1%) Mixed 103 (11%) Other 8 (1%) Not known 11 (1%) - Diagnosis of maternal infection (N=908 vertically infected) Known after delivery 774 (85%) Known before delivery 117 (13%) Not known 17 (2%)

10. 658 (69%) London 19 (2%) Scotland 210 (22%) Rest of England 60 (6%) Ireland 7 (1%) Wales Regional distribution of main follow-up centre for 954 children alive and followed up in CHIPS Children who have died, lost to follow-up, left the UK & Ireland or transferred to adult care are excluded

11. Year of last follow-up (N=954)

12. Clinical stage by age at last follow-up (N=954) Number of children:Total (col %) 1657180164417 (44%) 21991157269 (28%) 1638100114268 (28%)

13. Antiretroviral drug experience N=942 children with follow-up since January 2004 0% 20% 40% 60% 80% <2 years2-4 years5-9 years>=10 years % of children Naïve 1-4 drugs 5-7 drugs >=8 drugs Number of children:Total (col %) 8279087212 (23%) 2273186153434 (46%) 41170124209 (22%) 01226487 (9%)

14. ART at last follow-up N=623 children with follow-up since Jan 2004 were on treatment 1 on mono, 17 on dual, 545 on 3-drug, 57 on 4-drug and 3 on 5(+)-drug therapy

15. Most recent CD4% (N=934) Children followed up since January 2004 (missing for 8 children)

16. Most recent HIV RNA viral load (N=929) Children followed up since January 2004 (missing for 13 children)