1. Use of Single Data Source Can Significantly Underestimate Hepatitis C Mortality Rates Slideset on: Wu C, Chang HG, McNutt LA, Smith PF. Estimating the mortality rate of hepatitis C using multiple data sources. Epidemiol Infect. 2005;133:121-125.

2. clinicaloptions.com/hep Estimating Mortality Rates of Hepatitis C Background and Rationale  Hepatitis C major cause of liver disease in the US –3.9 million people infected with HCV in the US –75-85% develop chronic liver infection –Can lead to liver cirrhosis and hepatocellular carcinoma –8000-10,000 HCV-related deaths/year  Current study evaluated hepatitis C mortality rate in upstate New York –Accuracy of hepatitis C coding in hospitals investigated Wu C, et al. Epidemiol Infect. 2005;133:121-125.

3. clinicaloptions.com/hep Estimating Mortality Rates of Hepatitis C Summary of Study Design  Total number of hepatitis C-related deaths in New York State for 1997 –Not including New York City  New York State hospital discharge database –All in-patient admissions into non-federal, non-psychiatric hospitals included –Hepatitis C mortality: discharge coded as death from hepatitis C  New York State multiple cause-of-death file –Hepatitis C mortality: death with hepatitis C on file as primary or secondary condition Wu C, et al. Epidemiol Infect. 2005;133:121-125.

4. clinicaloptions.com/hep Estimating Mortality Rates of Hepatitis C Hepatitis C Mortality Rates Hepatitis C MortalityDischarge DatabaseCause-of-Death Database Number of deaths15887 Mortality rate (deaths/100,000 population) 1.40.8  Combined data using capture-recapture method –Significantly higher estimate of mortality rate than either database alone –4.5 deaths/100,000 population; 95% CI, 3.2-5.7 –Males have higher mortality rate than females –Males: 6.1 deaths/100,000 population; 95% CI, 4.0-8.2 –Females: 2.9 deaths/100,000 population; 95% CI, 1.6-4.3 Wu C, et al. Epidemiol Infect. 2005;133:121-125.

5. clinicaloptions.com/hep Estimating Mortality Rates of Hepatitis C Key Conclusions  Single data sources drastically underestimate mortality rate from hepatitis C  Estimated more accurately by combining data from various sources –Capture-recapture method successful at comparing data from different databases  Hepatitis C mortality rates are higher for men than women in New York state Wu C, et al. Epidemiol Infect. 2005;133:121-125.