1. The Rough Endoplasmic Reticulum (ER)
By :
Lidia Fetfatzes
&
Rebecca Abreu

2. Rough ER
The rough ER gets its name from the presence of ribosomes, which makes the surface look bumpy and is mainly composed of flattened sacs.
Ribosomes are small circular structures that control protein synthesis.

3. Ribosomes
Flattened Sacs
Vesicles
Rough ER

4. Function of the rough ER
The function of the rough ER is protein synthesis.
During protein synthesis, the ribosomes on the rough ER create new proteins. The ER then folds them properly and sorts them according to their function and destination.
As protein synthesis increases the rough ER expands, providing more surface area for ribosomes to spread out and create more proteins.

5. Function of the rough ER (Cont.)
The rough ER carries out its protein folding activity deep within the cisternal space.
Most proteins produced by ribosomes of the rough ER are destined for secretion out of the cell.

6. What would happen if the rough ER stopped functioning?
you wouldn't have the following: - transmembrane receptors - digestive enzymes - production and storage of glycogen and steroids
because they are involved in the transport of proteins.

7. Fibrinogen storage disease
Fibrinogen storage disease is a form of Endoplasmic Reticulum Storage Disease. (ERSD)
It’s the accumulation of proteins destined for secretion.
It’s permanent and affects mainly the rough endoplasmic reticulum (RER).

8. Rough ER seen through the Electron Microscope
The rough ER is not easily visible with a light microscope, but it can be seen with an electron microscope.
Rough ER seen through the Electron Microscope
Electron Microscope

9. The rough ER is so named because it has an abundance of _______________ on it.
Golgi bodies
Mitochondria
Lysosomes
Vesicles
Ribosomes