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Genital Tract Infections

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Presentation on theme: "Genital Tract Infections"— Presentation transcript:

1 Genital Tract Infections
King Khalid University Hospital Department of Obstetrics & Gynecology Course 481 Genital Tract Infections

2 Normal vaginal discharge
The normal vaginal flora is predominately aerobic organisms The most common is the H+ peroxide producing lactobacilli The normal PH is <4.5

3 Normal vaginal discharge
Normal vaginal secretions In reproductive aged women it consists of 1-4 mL fluid (per 24 hours), white or transparent, thick or thin, and mostly odorless. formed by mucoid endocervical, sloughing epithelial cells, normal vaginal flora, and vaginal transudate. ↑ in the middle of the cycle because of (physiologic leukorrhea)↑ in the amount of cervical mucus: during ovulation, pregnancy and in patient using OCP.

4 Abnormal vaginal discharge(vaginitis)
Extremely common signs and symptoms are generally similar Women with vaginitis present with one or more of the following vulvovaginal signs and symptoms: -Change in the volume, color, or odor of vaginal discharge -Pruritus, burning, Irritation, erythema -Dyspareunia, dysuria -Spotting The most common causes of vaginitis symptoms: bacterial vaginosis, candida vulvovaginitis and trichomoniasis (>90% of cases).

5 Bacterial Vaginosis (BV)
It is caused by alteration of the normal flora, with over-growth of anaerobic bacteria It is triggered by ↑ PH of the vagina (intercourse, douches) Recurrences are common May present with Fishy odor (especially after intercourse) no dyspareunia Increases risk for: -in pregnant women (PTL, endometritis and postpartum fever) -Post-hysterectomy vaginal-cuff cellulites -Postabortal infection -Acquiring other STDs, especially HIV

6

7 Bacterial Vaginosis (BV)
Diagnosis: Amstel Criteria Homogenous, grayish-whitish discharge Presence of clue cells PH >4.5 +ve whiff test(amine test) (adding KOH to the vaginal secretions will give a fishy odor) in 70-80% of cases “Clue cells are the most reliable predictor of BV”

8 Clue Cells

9 Bacterial Vaginosis (BV)
Treatment: Flagyl 500mg Po Bid for one week (95% cure) Flagyl 2g PO x1 (84% cure) Flagyl gel PV Clindamycin cream PV Clindamycin PO Treatment of the partner is not recommended

10 Trichomonas Vaginalis
It is an anaerobic parasite, that exists only in trophozite form 60% of patients also have BV 70% of males will contract the disease with single exposure Patients should be tested for other STDs (HIV, Syphilis)

11 Trichomonas Vaginalis
Diagnosis: Profuse, frothy ,purulent malodorous discharge It may be accompanied by vulvar pruritis Secretions may exudate from the vagina If severe → patchy vaginal edema and strawberry cervix PH >5 Microscopy: motile trichomands and ↑ leukocytes Clue cells may if BV is present Whiff test may be +ve

12 Wet Mount Trichomonads seen only in 50 – 70% Elevated pH
Can increase leukocytes Paps

13 Trichomoniasis

14 Trichomoniasis

15 Trichomonas Vaginalis
Treatment: Falgyl PO (single or multi dose) Flagyl gel is not effective The partner should be treated

16 Candidiasis 75% of women will have at least once during their life
45% of women will have two or more episodes/year 90% of yeast infections are secondary to Candida Albican Other species (glabrata, tropicalis) tend to be resistant to treatment

17 Candidiasis Predisposing factors:
Antibiotics: disrupting the normal flora by ↓ lactobacilli Pregnancy (↓ cell-mediated immunity) Diabetes

18 Candidiasis Diagnosis:
Symptoms: Vulvar pruritis and burning Vaginal soreness an dysparunea and splash dysuria The discharge vary from watery to thick cottage cheese discharge O/E: erythema and edema of the labia and vulva &the vagina may be erythematous with adherent whitish discharge PH< 4.5budding yeast or mycelia on microscopy Microscopic saline wet mount : Pseudohyphae (in about 70 percent of patients) Culture if microscopy nondiagnostic

19 Candidiasis

20 Candidiasis Treatment: Topical Azole drugs (80-90% effective)
Fluconazole is equally effective (Diflucan 150mg PO x1), but symptoms will not disappear for 2-3 days 1% hydrocortisone cream may be used as an adjuvant treatment for vulvar irritation Chronic infections may need long-term treatment (6 months) with weekly Fluconazole

21 Other Causes of Vaginitis
Atrophic vaginitis (in post mepausal women) High vaginal pH, thin epithelium, d/c Parabasal cells on wet mount Topical estrogen cream Atypical manifestations: HSV, HPV Noninfectious vulvovaginitis Irritants/allergens Lichens syndromes (sclerosus, simplex chronicus, planus) Cytolytic vaginitis

22 Herpes Simplex Virus HSV – 1 HSV – 2 Primary infections
Mostly oro-labial, but increasing cause of genital herpes HSV – 2 Almost entirely genital > 95% of recurrent genital lesions Primary infections Recurrent infections Latency

23 Transmission Horizontal Transmission Vertical Transmission
Intimate sexual contact (oral/genital) Aerosol and fomite transmission is rare Vertical Transmission Maternal-infant via infected cervico-vaginal secretions, blood or amniotic fluid at birth Autoinoculation From one site to another

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25 Diagnosis Viral isolation (culture)
High specificity, low sensitivity 50% for primary infxn 20% for recurrent infxn Direct detection of virus (Tzcank smears, PCR) Serology Newer tests that are specific for type of virus (HerpesSelect 2, herpes glycoprotein for IgG, ELISA)

26 Oral Antiviral Therapy
Valacyclovir (Valtrex) Famciclovir (Famvir) Acyclovir (Zovirax)

27 Genital Warts Condyloma accuminata secondary to HPV infection (usually 6&11), these are non-oncogenic types HPV Types 16 and 18 (oncogenic type) are the most commonly isolated HPV types in cervical cancer Usually at areas affected by coitus (posterior fourchette) 75% of partners are infected when exposed Recurrences after treatment are secondary to reactivation of subclinical infection

28 Genital Warts

29 Genital Warts

30 Cervicitis Neisseria Gonorrhea and Chlamydia Trachomatis infect only the glandular epithelium and are responsible for mucopurulent endocervisitis (MPC) Ectocx epithelium is continuous with the vaginal epithelium, so Trichomonas, HSV and Candida may cause ectocx inflammation

31 Cervicitis Tests for Gonorrhea (culture on Thayer- martin media) and Chlamydia (ELISA, direct IFA) should be performed

32 Pelvic Inflammatory Disease (PID)
Ascending infection, ? Up to the peritoneal cavity Organisms: Chlamydia, N Gonorrhea Less often: H Influenza, group A Strept, Pneumococci, E-coli

33 Fitz-Hugh-Curtis

34 PID Diagnosis: difficult because of wide variation of signs and symptoms Clinical triad: fever, pelvic pain and cervical motion and adnexal tenderness Cervical motion tenderness indicate peritoneal inflammation Patients may or may not have mucopurulent discharge

35 Sequelae Infertility -In 20% of patients Ectopic pregnancy
-infertility rate increase direct with number of episodes of acute pelvic infection Ectopic pregnancy -increase 6-10 fold Chronic pelvic infection -4 fold increase TOA -10% risk -if rupture high mortality rate

36 CDC Recommended treatment regimens for OPD of acute PID

37 Tubo-ovarian Abscess (TOA)
End-stage PID Causes agglutination of pelvic organs (tubes, ovaries and bowel) 75% of patients respond to IV antibiotics Drainage may be necessary Surgical treatment

38 Tubo-ovarian Abscess (TOA)

39 Thank you


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