1. Slide 1 of 41 What happens to produce?  All males are mutant, but all females are wild-type?  All females are wild type, but only 50% of males are?  50% are wild-type, 50% are mutant?

2. Slide 2 of 41 What happens to produce? (Answers)  All males are mutant, but all females are wild-type?  Wild-type dad + Mutant mom (homozygous recessive)  All females are wild type, but only 50% of males are?  Wild-type dad + Heterozygous Mom  50% are wild-type, 50% are mutant for both genders?  Mutant dad + Heterozygous Mom

3. Slide 3 of 41 Think about it…  IF the mother is homozygous dominant, then sons are   IF the mother is heterozygous, then sons are   IF the mother is homozygous recessive, then sons are

4. Slide 4 of 41 Think about it… (Answers)  IF the mother is homozygous dominant, then sons are  100% wild-type  IF the mother is heterozygous, then sons are  50% wild-type  IF the mother is homozygous recessive, then sons are  0% wild-type

5. Slide 5 of 41 Think about it… (Page 2)  IF the father is wild-type, then daughters are   IF the father is mutant, then daughters are   So mothers determine ______ & wild type fathers produce ______ daughters

6. Slide 6 of 41 Think about it… (Page 2) (Answers)  IF the father is wild-type, then daughters are  100% Wild-type  IF the father is mutant, then daughters are  Follow the mother’s type  So mothers determine sons & wild type fathers produce wild-type daughters

7. Slide 7 of 41 Sex-linked Disorders?  Which gender do you think is afflicted at a higher rate?  Why?

8. Slide 8 of 41 Sex-linked Disorders? (ANSWER)  Which gender do you think is afflicted at a higher rate?  Males  Why?  Biologically inferior?  XY means what they inherit from mom determines whether sons are diseased or not  XX gets an allele from mom and another from dad  So two chances to get the normal allele, and the normal allele is dominant to the disease allele

9. Slide 9 of 41 What should have happened?  What should have been the ratio if the characters were inherited via a Mendelian pattern?  How do the recombinants form?

10. Slide 10 of 41 What should have happened?  What should have been the ratio if the characters were inherited via a Mendelian pattern?  1:1:1:1  How do the recombinants form?  Parental and recombinant types are equally likely according to a typical Mendelian inheritance pattern