1. ISBE-AstraZeneca Strategic Alliance Project 5 Ninth meeting of the Strategic Alliance ISBE, University of Manchester 29 September 2003 Measurement of blood volume and endothelial permeability in non-malignant lung disease Progress Report

2. ISBE-AstraZeneca Strategic Alliance Project 5 Project objective Progress Report To investigate the ability of dynamic parametric imaging to produce meaningful and reproducible images of normal lung parenchyma and lung tissue involved in inflammatory lung diseases

3. ISBE-AstraZeneca Strategic Alliance Project 5 Background Progress Report Existing T 1 -weighted dynamic contrast enhanced MRI study of neoplastic lung disease (-separate University of Manchester/ AstraZeneca collaboration) Dynamic data modelled to obtain transfer constant K trans (related to permeability), vascular blood volume v b, extravascular extracellular space volume v e Investigate contrast enhancement in areas of lung tissue outside tumour

4. ISBE-AstraZeneca Strategic Alliance Project 5 Axial T1-weighted images indicating ROI position for lung parenchyma measurements. Measurements were possible in 3 of 4 patients. Pats 1,2,4. Grey scale windowed to demonstrate the presence of signal in the ROIs Progress Report

5. ISBE-AstraZeneca Strategic Alliance Project 5 Axial T1-weighted images indicating ROI position for lung parenchyma measurements. Measurements were possible in 3 of 4 patients. Pats 1,2,4. Grey scale windowed to demonstrate the presence of signal in the ROIs Progress Report

6. ISBE-AstraZeneca Strategic Alliance Project 5 Axial T1-weighted images indicating ROI position for lung parenchyma measurements. Measurements were possible in 3 of 4 patients. Pats 1,2,4. Grey scale windowed to demonstrate the presence of signal in the ROIs Progress Report

7. ISBE-AstraZeneca Strategic Alliance Project 5 lung parenchyma ROI concentration time courses and model fits. Progress Report

8. ISBE-AstraZeneca Strategic Alliance Project 5 lung parenchyma ROI concentration time courses and model fits. Progress Report

9. ISBE-AstraZeneca Strategic Alliance Project 5 lung parenchyma ROI concentration time courses and model fits. Progress Report