1. Essentials of Human Anatomy & Physiology Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slides 9.23 – 9.41 Seventh Edition Elaine N. Marieb Chapter 9 The Endocrine System Lecture Slides in PowerPoint by Jerry L. Cook

2. Thyroid Gland Slide 9.23a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Found at the base of the throat  Consists of two lobes and a connecting isthmus  Produces two hormones  Thyroid hormone (T3 & T4)  Calcitonin

3. Thyroid Gland Slide 9.23b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 9.6

4. Thyroid Hormone Slide 9.24 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Major metabolic hormone  Composed of two active iodine- containing hormones  Thyroxine (T 4 ) – secreted by thyroid follicles  Triiodothyronine (T 3 ) – conversion of T 4 at target tissues

5. Calcitonin Slide 9.25 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Decreases blood calcium levels by causing its deposition on bone  Antagonistic to parathyroid hormone  Produced by C (parafollicular) cells Figure 9.9

6. Parathyroid Glands Slide 9.26 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Tiny masses on the posterior of the thyroid  Secrete parathyroid hormone (PTH)  Stimulate osteoclasts to remove calcium from bone  Stimulate the kidneys and intestine to absorb more calcium  Raise calcium levels in the blood

7. Adrenal Glands Slide 9.27 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Two glands  Cortex – outer glandular region in three layers  Medulla – inner neural tissue region  Sits on top of the kidneys

8. Hormones of the Adrenal Cortex Slide 9.28a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Mineralocorticoids (mainly aldosterone)  Produced in outer adrenal cortex  Regulate mineral content in blood, water, and electrolyte balance  Target organ is the kidney (Na & water)  Production stimulated by renin and aldosterone  Production inhibited by atrial natriuretic peptide

9. Hormones of the Adrenal Cortex Slide 9.28b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 9.10

10. Hormones of the Adrenal Cortex Slide 9.29a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Glucocorticoids (including cortisone and cortisol)  Produced in the middle layer of the adrenal cortex  Promote normal cell metabolism  Help resist long-term stressors (anti allergy)  Released in response to increased blood levels of ACTH

11. Hormones of the Adrenal Cortex Slide 9.29b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Sex hormones  Produced in the inner layer of the adrenal cortex  Androgens (male) and some estrogen (female)

12. Hormones of the Adrenal Medulla Slide 9.30 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Produces two similar hormones (catecholamines)  Epinephrine  Norepinephrine  These hormones prepare the body to deal with short-term stress

13. Roles of the Hypothalamus and Adrenal Glands in the Stress Response Slide 9.31 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 9.12

14. Pancreatic Islets Slide 9.32a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  The pancreas is a mixed gland  The islets of the pancreas produce hormones  Insulin – allows glucose to cross plasma membranes into cells from beta cells  Glucagon – allows glucose to enter the blood from alpha cells  These hormones are antagonists that maintain blood sugar homeostasis

15. Pancreatic Islets Slide 9.32b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 9.13

16. Pancreatic Hormones and Blood Sugar Slide 9.33 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 9.14

17. Pineal Gland Slide 9.34 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Found on the third ventricle of the brain  Secretes melatonin  Helps establish the body’s wake and sleep cycles  May have other as-yet-unsubstantiated functions

18. Thymus Slide 9.35 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Located posterior to the sternum  Largest in infants and children  Produces thymosin  Matures some types of white blood cells Tcells  Important in developing the immune system

19. Hormones of the Ovaries Slide 9.36 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Estrogens  Produced by Graafian follicles or the placenta  Stimulates the development of secondary female characteristics  Matures female reproductive organs  Helps prepare the uterus to receive a fertilized egg  Helps maintain pregnancy  Prepares the breasts to produce milk

20. Hormones of the Ovaries Slide 9.37 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Progesterone  Produced by the corpus luteum  Acts with estrogen to bring about the menstrual cycle  Helps in the implantation of an embryo in the uterus

21. Hormones of the Testes Slide 9.38 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Interstitial cells of testes are hormone- producing  Produce several androgens  Testosterone is the most important androgen  Responsible for adult male secondary sex characteristics  Promotes growth and maturation of male reproductive system  Required for sperm cell production

22. Other Hormone-Producing Tissues and Organs Slide 9.39 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Parts of the small intestine  Parts of the stomach  Kidneys  Heart  Many other areas have scattered endocrine cells

23. Endocrine Function of the Placenta Slide 9.40 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Produces hormones that maintain the pregnancy  Some hormones play a part in the delivery of the baby  Produces HCG in addition to estrogen, progesterone, and other hormones

24. Developmental Aspects of the Endocrine System Slide 9.41 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Most endocrine organs operate smoothly until old age  Menopause is brought about by lack of efficiency of the ovaries  Problems associated with reduced estrogen are common  Growth hormone production declines with age  Many endocrine glands decrease output with age