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Bioresponsive nanosensors in medical imaging by Eyk Schellenberger Interface Volume 7(Suppl 1):S83-S91 February 6, 2010 ©2010 by The Royal Society.

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Presentation on theme: "Bioresponsive nanosensors in medical imaging by Eyk Schellenberger Interface Volume 7(Suppl 1):S83-S91 February 6, 2010 ©2010 by The Royal Society."— Presentation transcript:

1 Bioresponsive nanosensors in medical imaging by Eyk Schellenberger Interface Volume 7(Suppl 1):S83-S91 February 6, 2010 ©2010 by The Royal Society

2 Types of imaging probes. Eyk Schellenberger J. R. Soc. Interface 2010;7:S83-S91 ©2010 by The Royal Society

3 Principle of fluorescent smart probes. Eyk Schellenberger J. R. Soc. Interface 2010;7:S83-S91 ©2010 by The Royal Society

4 VSOPs were originally developed for MR angiography. Eyk Schellenberger J. R. Soc. Interface 2010;7:S83-S91 ©2010 by The Royal Society

5 Superparamagnetic nanoparticles for sensing apoptosis. Eyk Schellenberger J. R. Soc. Interface 2010;7:S83-S91 ©2010 by The Royal Society

6 Principle of an activatable PSOP. (a) A model of a PSOP. Based on electrostatically stabilized VSOPs, the nanoparticles contain a 5 nm superparamagnetic iron oxide core (grey) coated with a monomeric, anionic citrate shell (red). Eyk Schellenberger J. R. Soc. Interface 2010;7:S83-S91 ©2010 by The Royal Society

7 Time courses of in vitro activation of MMP-2/9-PSOPs by MMP-9. Eyk Schellenberger J. R. Soc. Interface 2010;7:S83-S91 ©2010 by The Royal Society


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