2. 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple Myeloma 4.Staging and prognosis 5.Treatment strategies

3. MGUS Myeloma Monoclonal gammopathy +CRAB Poems Waldenstrom’ s macroglobuli nemia Amyloid Monoclonal gammopathy+ Amyloid deposition in the tissue

13. Copyright ©2010 American Society of Haematology. Copyright restrictions may apply. Ghobrial, I. M. et al. ASH-SAP 2010;2010:581-604 Table 20-1 Diagnostic criteria for monoclonal gammopathies

18. Risk of progression of MGUS to myeloma or related disorder using a risk-stratification model that incorporates the FLC ratio and the size and type of the serum monoclonal protein. Rajkumar S V et al. Blood 2005;106:812-817 ©2005 by American Society of Hematology

19. *Impact of optimal follow-up of monoclonal gammopathy of undetermined significance on early diagnosis and prevention of myeloma-related complications Blood 2010, Bianchi et al

27. Copyright ©2010 American Society of Hematology. Copyright restrictions may apply. Ghobrial, I. M. et al. ASH-SAP 2010;2010:581-604 Table 20-4 Staging systems for multiple myeloma: Durie-Salmon staging system and International Staging System (ISS)‏

28. Interaction between Plasma Cells and Bone Marrow in Multiple Myeloma. Palumbo A, Anderson K. N Engl J Med 2011;364:1046-1060

29. Patient with myeloma Transplant eligible Induction therapy 2-4 cycles Induction therapy Transplant ineligible Induction therapy Upfront transplant Delayed Transplant maintenance Maintenance

51. QUESTIONS/COMMENTS