1. Cognitive Psychology PSYC231 Cognition and the Brain: Basic Principles 2 Dr. Jan Lauwereyns, EA619, ext. 5042

3. Broca: Production, Syntax Wernicke: Comprehension, Meaning

4. Figure 2.22 (p. 46) (a) When a monkey is looking at the X and is not paying attention to the flashing light that is off to the side, a neuron in the cortex fires slowly; (b) when the monkey pays attention to the light (while still looking at the X) firing of the neuron increases.

5. Techniques for Studying the Physiology of Cognition

6. Electrical recording techniques

7. Human electrophysiology Electro-encephalo-graphy (E.E.G.): e.g., used for detecting different sleep phases Recording electrical signal from the scalp Faint, noisy Moderate spatial resolution, but very accurate temporal resolution (ms) Can be used for cognitive experiments: ERP –Averaging –Relating to events: “Event-Related Potential”

8. Less popular now, but… ERP research was very popular in the 80s and early 90s, now losing momentum Related technique of MEG (magneto-encephalo- graphy), better spatial resolution but too expensive

9. Invasive techniques Electrode in the brain

10. Deep-brain stimulation in patients with Parkinson’s disease

11. Self-stimulation of subthalamic nucleus (in the basal ganglia): Patients can move their arms and legs again

12. Animal models Single-unit studies, recording electrical discharges of individual neurons Cat (Hubel & Wiesel) Monkey Rat Correlate neuronal activity with task events in simple behavioural paradigms Best possible temporal and spatial resolution But: cost, external validity Well defined, hypothesis driven

13. Neural robotics: Miguel Nicolelis

14. Functional imaging studies Functional imaging: record brain activity during task performance As opposed to Structural imaging, measuring tissue density only (for diagnostic purposes) Put S in scanner, the whole brain lights up Data are only as good as the logic of the experiment – this is where Psychology steps in Subtraction method with task components Let’s look at “spec sheet” of PET and fMRI…

15. Positron Emission Tomography (PET) Inject radioactively tagged substance (e.g., O 2, glucose) Map the uptake of the substance (photocells)

16. Pro’s and con’s of PET Not only cerebral blood flow: –Example: Koepp et al, 1998, Nature: Measure dopamine release while participants play a video game (reduced binding in ventral striatum) Drawbacks: –involves radiation –poor temporal resolution (tens of seconds, minutes)

17. functional Magnetic Resonance Imaging (fMRI) Map rates of O 2 uptake –Loss of O 2 causes magnetic changes to blood –Non-invasive

18. Most important pro: –Temporal resolution better –With the most powerful scanners it is possible to map changes in blood flow in a few seconds (event fMRI)

19. But: –Noise: even small movements (eye blink) –Requires averaging across samples –Problems with inter-individual differences –Preferably multiple samples from the same S

20. Doesn’t come cheap…

21. Transcranial magnetic stimulation Deliver a fairly localized magnetic current while participants perform a task Not really “invasive” in the sense that nothing mechanical is put in the brain Long-term effects not known

22. Lesion or subtraction method (Neuropsychology) Dr. Carolyn Wilshire Patients with specific brain damage Compared with normals How do the patients perform differently in behavioral/cognitive tests? Single or double dissociation (broken TVs) No control over size and site of damage Animal models