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Published byScot Henry Modified over 9 years ago
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Maintain internal homeostasis. Regulate body temperature Maintain tissue and cellular pH.
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Cardiac fibroblast Vascular cells Purkinje cells Connective tissue cells Cardiac myocytes
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Alcoholic Cardiomyopathy Peripartum Cardiomyopathy
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There are several different injury mechanism associated with cardiac toxicants. Generation of free redicals Lipid peroxidation Impaired membrane integrity Mitochondrial dysfunction Sarcoplasmic reticulum dysfunction Altered calcium homeostasis
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Direct and indirect damage to the hematopoietic system may produce hypoxia, hemorrhage, infection and death. Primary hematotoxicity Secondary hematotoxicity
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Ethanol Sideroblastic anemia Benzene Aplastic anemia Vinyl chloride Acquride prophyria NitratesMethemoglobinemia AntimonyNeutropenia ArsineThrombocytopenia Methyl chloride Hemolytic anemia Warfarin Alteration in blood clotting system Alkylating agents Agranulocytopenia
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