1. Fear Conditioning Michael Davis’ Ponca Symposium Presentation (notes from)

2. Conditioning  Stimulus – e.g. food  Response – e.g. salivation  Conditioned Stimulus (CS) –Bell rung always just before the food –i.e. paired with unconditioned stimulus  US  Conditioned Response (CR) –Unpaired with US (bell without food) –Salivation  Same as UR

3. Fear Conditioning  Unconditioned Stimulus (US) – shock  Unconditioned Response (UR) – freezing  CS –Light or sound (cannot cause UR alone) –i.e. paired with US  CR –Unpaired with US (sound without shock) –Freezing  Same as UR

4. Fear Conditioning - another example  US – sudden loud noise  UR – startle  CS ~ Fear Stimulus – shock or predator –Pairing fear stimulus with US produces a greater startle response Following training  US alone produces… ………..enhanced fear startle

5. Extinction of Fear Conditioning  Extinction is NOT an erasure of original fear memory  Extinction Actively inhibits memory  Extinction is Context specific  Extinction of Fear may be disrupted by stress

6. Fear Conditioning Neurocircuitry Perirhinal Ctx Retina LGN Visual Ctx Visual Pathway LA + BLA CeAAmygdalaStartle Ear CRN PnC Spinal Cord Deep Sc/Me

7. Extinction Actively Inhibits Fear Memory