2. Objectives Know radiation and mutagenic chemicals increase the mutation rate and can cause genetic diseases and cancer. Application: Consequences of radiation after nuclear bombing of Hiroshima and the Chernobyl. Outcomes 3: Describe causes and consequences of mutation. 5: Explain the effects of large doses of radiation such as in Hiroshima and Chernobyl. 7: Evaluate the short and long term consequences of misuse of nuclear radiation. Key terms: radiation, mutagenic, cancer, genetic disease.

3. A mutagenic substance or mutagen is a physical or chemical agent with the potential to change DNA. Examples include: Radiation Various chemicals Viruses Bacteria Outcomes 3: Describe causes and consequences of mutation. 5: Explain the effects of large doses of radiation such as in Hiroshima and Chernobyl. 7: Evaluate the short and long term consequences of misuse of nuclear radiation. Key terms: radiation, mutagenic, cancer, genetic disease.

4. What are the results of mutation?Outcomes 3: Describe causes and consequences of mutation. 5: Explain the effects of large doses of radiation such as in Hiroshima and Chernobyl. 7: Evaluate the short and long term consequences of misuse of nuclear radiation. Key terms: radiation, mutagenic, cancer, genetic disease. Cancers Genetic disease New characteristics Eventual evolution? Nothing!

5. What are the results of mutation?Outcomes 3: Describe causes and consequences of mutation. 5: Explain the effects of large doses of radiation such as in Hiroshima and Chernobyl. 7: Evaluate the short and long term consequences of misuse of nuclear radiation. Key terms: radiation, mutagenic, cancer, genetic disease. Cancers Genetic disease New characteristics Eventual evolution? Nothing!

6. In genetics, the mutation rate is a measure of the rate at which various types of mutations occur over time. Mutation rates are typically given for a specific class of mutation, for instance point mutations, small or large scale insertions or deletions. Outcomes 3: Describe causes and consequences of mutation. 5: Explain the effects of large doses of radiation such as in Hiroshima and Chernobyl. 7: Evaluate the short and long term consequences of misuse of nuclear radiation. Key terms: radiation, mutagenic, cancer, genetic disease.

7. Case studies Hiroshima Chernobyl For each: What When Where Why Short term consequences Long term consequences Outcomes 3: Describe causes and consequences of mutation. 5: Explain the effects of large doses of radiation such as in Hiroshima and Chernobyl. 7: Evaluate the short and long term consequences of misuse of nuclear radiation. Key terms: radiation, mutagenic, cancer, genetic disease.