1. Development of the central nervous system Sanjaya Adikari Department of Anatomy

2. Neural tube & cavity

3. 1 2 3 Prosencephalon (forebrain) Mesencephalon (midbrain) Rhombencephalon (hindbrain) 1a 2 3a 1b 3b Development of brain

4. 1a 2 3a 1b 3b Telencephalon Cerebral hemispheres Diencephalon Midbrain tectum, tegmentum and cerebral pedunculi Metencephalon pons, upper medulla and cerebellum Myelencephalon lower medulla Thalamus, hypothalamus subthalamus, epithalamus

5. Lateral ventricle Foramen of Monro Aqueduct 4 th ventricle Central canal of SC 3 rd ventricle

6. Development of spinal cord and brain stem Mantle layer Marginal layer Neuroepithelial layer

7. Neuroepithelial cells Gliablast cells Neuroblast cells Neurons Glial cells 1 2 OligodendrogliaAstroglia MicrogliaEpendymal cells

8. Alar plate (sensory) Basal plate (motor) Sulcus limitans Mantle layer Marginal layer Neuroepithelial layer

9. Posterior horn Lateral horn Anterior horn Motor Sensory Motor Sensory

10. BE BA SE VE VA GSA