1. Water deprivation induces appetite and alters metabolic strategy in Notomys alexis: unique mechanisms for water production in the desert by Yoshio Takei, Ray C. Bartolo, Hiroaki Fujihara, Yoichi Ueta, and John A. Donald Proceedings B Volume ():rspb20112627 March 7, 2012 ©2012 by The Royal Society

2. Time-course changes in food intake and body mass during water deprivation (WD) (filled circles) and free access to drinking water (open circles) in (a,b) desert mice (Notomys) and (c,d) laboratory mice of Balb-C strain (Mus). Yoshio Takei et al. Proc. R. Soc. B doi:10.1098/rspb.2011.2627 ©2012 by The Royal Society

3. Changes in body mass, body fat and plasma leptin, ghrelin and Na+ concentrations after WD in (a–e) desert mice (Notomys, n = 6–8 at each time point) and (f–j) laboratory mice of Swiss strain (Mus, n = 10 at each time point). Yoshio Takei et al. Proc. R. Soc. B doi:10.1098/rspb.2011.2627 ©2012 by The Royal Society

4. Changes in the expression of neuropeptide genes in the hypothalamus after WD in (a–g) desert mice (Notomys, n = 6–8) and (h–n) laboratory mice of Swiss strain (Mus, n = 10). Yoshio Takei et al. Proc. R. Soc. B doi:10.1098/rspb.2011.2627 ©2012 by The Royal Society

5. Changes in liver and muscle glycogen contents, hepatic glycogen synthase gene expression and plasma glucose and corticosterone concentrations after WD in (a–e) desert mice (Notomys, n = 6–8) and (f–j) laboratory mice of Swiss strain (Mus, n = 10). Yoshio Takei et al. Proc. R. Soc. B doi:10.1098/rspb.2011.2627 ©2012 by The Royal Society

6. A schema showing interplay of regulatory systems for appetite and energy metabolism during WD in Notomys. Yoshio Takei et al. Proc. R. Soc. B doi:10.1098/rspb.2011.2627 ©2012 by The Royal Society