1. Introduction to Bioengineering Presented to Chabot College ENGR10 • Nov06
Ovijit Chaudhuri
PhD candidate
Department of Bioengineering,
University of California Berkeley
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 1

2. What is Bioengineering?
Applying engineering techniques/analysis and technology to biological and medical problems.
Some areas (biomedical engineering) are focused on medical applications and using technology for solutions to healthcare problems (traditional).
Others are focused on using engineering principles and ideas to understand the way biological systems are constructed.
Bioengineering is very interdisciplinary encompassing various fields.
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 2

3. Prosthetics – Hip replacement
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 3

4. Medical Imaging MRI, PET, CAT, etc … Cuellar Clinic website
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 4

5. Biomechanics How stiff does the hip replacement need to be?
What kind of loads will it experience?
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 5

6. Biomaterials Mechanical properties? Materials that are easy to mold?
What kind of materials are biocompatible?
Wear, tear, corrosion.
Immune Response?
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 6

7. Improving healthcare: Lab on a chip Devices
El-Ali, et al., Nature, 2006
Yager, et al., Nature, 2006
Whitesides, Nature, 2006
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 7

8. Drug Delivery Microjet injection device Fletcher lab, UC Berkeley
Glucose sensor/ delivery device
Gough lab, UCSD
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 8

9. Industry Hip replacement Other prosthetic devices
Cardiac stents (Guidant, Johnson and Johnson)
Other cardiac devices
Drug delivery devices
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 9

10. Understanding the “engineering” of biological systems - Computational Biology
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 10
Max Delbrueck Center Berlin-Buch

11. Understanding the “engineering” of biological systems - Synthetic Biology
Keasling lab, UC Berkeley
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 11

12. Understanding the “engineering” of biological systems -Tissue Engineering
Engler, et al., Cell, 2006
Kurpinski, et al., Cell, 2006
Nelson, et al., Science, 2006
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 12

13. Understanding the “engineering” of biological systems – cell mechanics and motility
David Rogers, Vanderbilt U.
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 13

14. Atomic Force Microscopy
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 14

15. Our Atomic Force Microscope
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 15

16. Growing actin networks power cell movement and provide rigidity
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 16
Svitkina, et al.,JCB, 1999

17. Our studies of actin networks
Parekh, et al., Nat. Cell Bio. 2005
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 17

18. Questions?
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 18