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RhBMP-2 Release from Injectable Poly(DL-Lactic-co- glycolic Acid)/Calcium-Phosphate Cement Composites by P. Quinten Ruhe, Elizabeth L. Hedberg, Nestor.

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Presentation on theme: "RhBMP-2 Release from Injectable Poly(DL-Lactic-co- glycolic Acid)/Calcium-Phosphate Cement Composites by P. Quinten Ruhe, Elizabeth L. Hedberg, Nestor."— Presentation transcript:

1 rhBMP-2 Release from Injectable Poly(DL-Lactic-co- glycolic Acid)/Calcium-Phosphate Cement Composites by P. Quinten Ruhe, Elizabeth L. Hedberg, Nestor Torio Padron, Paul H.M. Spauwen, John A. Jansen, and Antonios G. Mikos J Bone Joint Surg Am Volume 85(suppl 3):75-81 August 1, 2003 ©2003 by The Journal of Bone and Joint Surgery, Inc.

2 Scanning electron microscopy image of PLGA microparticles, showing the spherical shape of the microparticles. P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81 ©2003 by The Journal of Bone and Joint Surgery, Inc.

3 Microcomputed tomography image of 30:70 by weight PLGA/calcium-phosphate cement composite. P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81 ©2003 by The Journal of Bone and Joint Surgery, Inc.

4 Scanning electron microscopy image of 30:70 by weight PLGA/calcium-phosphate cement composite. P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81 ©2003 by The Journal of Bone and Joint Surgery, Inc.

5 Results of mechanical testing of calcium phosphate cement (Ca-P) and PLGA/calcium- phosphate cement composite. P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81 ©2003 by The Journal of Bone and Joint Surgery, Inc.

6 Results of LIVE/DEAD cytotoxicity assay of calcium phosphate cement (Ca-P). P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81 ©2003 by The Journal of Bone and Joint Surgery, Inc.

7 In vitro release of rhBMP-2-loaded PLGA microparticles and PLGA/calcium-phosphate cement composite in pH 7.4 and pH 4.0 under continuous shaking at 37°C, expressed as the ratio of total cumulative mass of rhBMP-2 released to total mass of rhBMP-2 entrapped. P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81 ©2003 by The Journal of Bone and Joint Surgery, Inc.

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