1. NSF CyberInfrastructure Linkages with “IT Issues” in the FDA Critical Path Initiative Sangtae “Sang” Kim, PhD National Science Foundation* presented at the FDA Science Board Advisory Committee Meeting Apr. 15, 2005 – Rockville, MD *Also Donald W. Feddersen Distinguished Professor, Purdue University (“on loan” to NSF)

2. 2 Goals for Today In 10 minutes or less, outline to the Science Advisory Board the linkages between NSF activities and “IT issues” in the FDA’s Critical Path Initiative Brief overview of most salient points that set the stage for inter-agency collaborations Additional background materials for the record, including current activities at two centers Some highlights: –NSF track record and emerging trends of interest to FDA –FDA RFID mandate as an example of driver for middleware –Digital archiving: encouraging inter-agency collaborations

3. 3 “Track Record” of NSF Activities in CI NSFnet + ARPAnet became the Internet The Past NCSA Mosaic project WWWeb browser, Apache web server Trend s Worldwide adoption of NSF “grid engines” Middleware is key to FDA RFID goals Digital archiving: SDSC NSF-NARA-LC &FDA

4. 4 CyberInfrastructure: Tipping Point Information Flow Reversal Topological view of the Internet Create & Compute at the core; then broadcast to the periphery Internet Historical Roots Massive data generated at the periphery; novel systems & architectures; revitalized core of high-end computers The Next Wave

5. 5 Big Picture Strategy Impact: Enabling role of CyberInfrastructure for S&E Research has a parallel paradigm for the trans- formative power of the next wave of the “e” revolution: immediate economic, societal impact Drivers: Massive data generation at the periphery, High End Computing (HEC) at the core, and a new architecture linking the core to the periphery - these are driving the central elements of CI What Success Looks Like: As we transition to next generation CI (e.g. RFID), continue tradition of U.S. leadership in deployed CI (strategic advantage)

6. 6 Background Information

7. 7 Background on Sang Kim Computational research in fluids, particulate and biological systems, UW-Madison, over 15-year span (elected to National Academy of Engineering, 2001) Served as V.P.for IT (“CIO” of R&D Labs) at two large pharmaceutical companies, 1997-2003 “Public Service” Advisory Boards/Councils: –NRC Board on Chem. Sciences & Technology 2000-2003 –NSF Engineering Directorate 2002-2004 –Others pending (deferred due to NSF service) NIH/NIGMS “On loan” to NSF from Purdue, Feb. 2004 to present, active research programs in informatics, RFID and self-assembly

8. 8 Guiding Principles for Shared CyberInfrastructure at NSF Serve all of science & engineering Firm and continuing commitment to providing the most advanced cyberinfrastructure (CI), with high- end computing (HEC) at the core –Tag line “HEC + X” Encourage emerging CI while maintaining and transitioning extant CI Provide balance in CI equipment Strong links to ongoing fundamental research to create future generations of CI

9. 9 Cyberinfrastructure: the future consists of … Computational engines (supercomputers, clusters, workstations – capability and capacity) Mass storage (disk drives, tapes, …) and persistence Networking (including optical, wireless, ubiquitous) Digital libraries/data bases Sensors/effectors (includes RFID) Software (operating systems, middleware, domain specific tools/platforms for building applications) Services (education, training, consulting, user assistance) All working together in an integrated fashion.