1. General Practice Research Framework INTRODUCTION Computer-tailored interventions can reach large sections of the population at a reasonable cost and are reported to be more effective in promoting behaviour change than standard materials. The UK government-funded initiatives do not include the option of a tailored approach for smokers who do not want intensive counselling. Therefore providing tailored feedback in primary care could complement existing services, helping to produce more quitters and reducing the UK smoking prevalence. A large trial of the effectiveness of computer-tailored feedback delivered to smokers identified from general practice records and recruited proactively (ESCAPE) is in progress, informed by a pilot study which demonstrated that recruiting smokers from general practice was successful in recruiting less motivated smokers, and smokers with low literacy levels. The ESCAPE trial aims to target smokers from areas of high deprivation using a proactive recruitment strategy to deliver tailored feedback to a large population. To ensure that the target population was reached, we used Carstairs scores which highlight deprivation within small populations, to select a representative sample of practices from the UK General Practice Research Framework (GPRF) database. Here we describe the strategy used for the recruitment of practices to the ESCAPE trial and the response. METHOD The MRC GPRF is a network of 1100 practices scattered throughout the UK. We aim to recruit 7250 smokers from 100 MRC GPRF practices selected to represent high and low socio-economic areas. Two methods were used to encourage GPRF practices to self-select into the ESCAPE study: 1. Advertisement: The study was advertised in the GPRF Newsletters with an ‘Expression of Interest Form’ for completion. 2. Personal Invitations: Those who did not express an interest in the study through the adverts in the GPRF Newsletters were sent a personal invitation. In order to ensure a good spread of practices, invitations were stratified by practice list size as shown below: RESULTS As a result of advertising, 98 GPRF practices originally expressed an interest in the study. However as a result of both methods above, 116 practices agreed to participate in the study, yielding a high overall response rate of 23%. This recruitment strategy resulted in a good spread of practices from the quintiles as shown below: CONCLUSION This recruitment strategy was successful in recruiting practices to the study and in recruiting practices from areas of high deprivation. Proactively recruiting smokers from general practices shows promise as way to deliver public-health interventions to all sectors of the smoking population given the positive response to the study. A Strategy for Targeting Smokers from High Deprivation Areas to a Computer-tailored Intervention using General Practice Records QuintilesEnglandScotlandWalesAll 175113 2155121 3293133 422123 526 Total99134116 As shown in the table, we managed to recruit a high proportion of practices in quintiles 5 (most deprived) even though there were a small number of practices within this quintile on the GPRF database. After practices self selected into the study, they were selected for participation after stratification for deprivation scores. Carstairs scores were used to rank practice postcodes from least deprived to most deprived, and wards were allocated to deprivation quintiles according to equal fifths of the population. Therefore a proportional selection was conducted from each quintile to ensure that the proportion of surgeries selected from each ward was representative of the population. For example, for England 7.6% of surgeries were in quintile 1; 10.3% in quintile 2; 16.2% in quintile 3; 22.2% in quintile 4 and 43.4% in quintile 5. Therefore of the 86 English practices needed, we hoped to recruit 7 from quintile 1; 9 from quintile 2; 14 from quintile 3; 19 from quintile 4 and 37 from quintile 5. RegionList sizeNos. invited East Anglia>399941 of 48 East Midlands>499938 of 67 North>399939 of 44 North West>399944 of 69 Yorks and Humber>499947 of 55 South East4000 – 4999 8000 – 8999 12000 – 12999 >15000 66 of 219 South West4000 – 5999 8000 – 11000 >13999 36 of 108 West Midlands4000 – 6000 7250 – 9000 >12999 35 of 68 Scotland>499938 of 54 WalesALL31 Camille Alexis-Garsee 1, Hazel Gilbert 1, Irwin Nazareth 1, Stephen Sutton 2 1 University College London 2 University of Cambridge