1. Endocrine System PA 544: Clinical Anatomy Tony Serino, Ph.D. Biology Department Misericordia Univ.

2. Endocrine System Controls and modifies the internal environment by releasing chemicals (hormones) into the blood Slower response time but longer duration of action compared to nervous system

3. Chemical Messengers (hormones) Hormone –secreted by cell into blood and acts on another cell some distance away Neurohormone –secreted by neuron into blood to affect a target cell some distance away Local hormones –secreted by cell into interstitial fluid to affects cells nearby –Paracrines –affect neighboring cells –Autocrines –affect the secreting cell Pheromones –secreted by cell onto body surface to affect cells of another individual

4. Hormones Chemical Classification –Amines –single or few amino acids, most water soluble Epinephrine, Thyroxine (but water insoluble), Melatonin –Proteins –short to long chains of amino acids; water soluble GH, FSH, LH, Insulin, Glucagon, ADH, etc. –Steroids –derivatives of cholesterol; water insoluble Estrogen, Testosterone, Progesterone, Cortisol, Aldosterone

5. Steroid Hormones

6. Characteristics Common to all Hormones Must have target cell with appropriate receptor molecules Receptor-hormone complex must trigger events in target cell that changes its physiology Mechanisms for deactivating the hormone response must be present

7. Controlling Hormone Response Half-life of the hormone Physiological range Modifying target cell response –Up and down regulation Turning off secretion –Negative feedback –Control by other hormones, neurons and metabolites

8. Control of Hormone Secretion

9. Mechanisms of Hormone Action Water Soluble Water Insoluble Carrier protein 2 nd messengers

10. 2 nd Messengers: cAMP

11. 2 nd Messengers: IP 3 and Ca ++ -Calmodulin

12. Steroid Hormone Transduction

13. Different Styles of Secretion Prohormone –a hormone that is made as a larger (inactive form) that must be changed prior to secretion (allows for storage of hormone in secreting cell) Ex.: proinsulin, pro-opiomelanocortin Prehormone –a hormone that is secreted in an inactive form that must be changed near or in the target cell Ex.: Thyroxine, Angiotensinogen

14. Proinsulin

15. Types of Endocrine Disorders Hypersecretion –Too much secretion of the hormone Hyposecretion –Too little secretion of hormone Hyporesponsiveness –Normal secretion, but little to no response by target cells

16. Endocrine Glands

17. Control of Growth Growth periods: prenatal and postnatal (consists of pre-puberal (especially the first 2 years –infancy) and puberty Several factors influence growth: genetics, diet, health, and hormonal balance Prenatal growth dominated by insulin secretion, post-natal dominated by GH, thyroxine, and sex hormones

18. GH secretion and effects GH secretion stimulated by exercise, fasting, sleep (diurnal rhythm), stress on bones, decreased plasma glucose, increased plasma AA (such as after a high protein meal) Increase differentiation Increase protein synthesis (increase mitosis)

19. GH interactions with other Hormones Thyroxine: essential and permissive for GH –Needed to maintain energy levels for growth –Increases sensitivity of target cells to GH effects Insulin: essential for GH effects –Dominant hormone for pre-natal growth Estrogen and Testosterone: surge at puberty stimulates GH release, synergistic with GH anabolism; also trigger epiphyseal closure Cortisol: anti-growth effects; decrease GH secretion, cell division, and increase catabolism

20. GH pathologies Hypersecretion: –Gigantism –in children with responsive epiphyseal plates –Acromegaly –in adults, with closed epiphyseal plates

21. GH pathologies Hypofunction: –Dwarfism –in children Pituitary –decreased GH secretion Laron –decreased responsiveness due to lack of GH receptors Achondroplastic Dwarfism (genetic dwarf) due to failure of cartilage to form in epiphyseal plate 28 yo woman with pituitary dwarfism; 45” tall