1. July 26th, 2004INFN-Genova Barbara Mascialino Overview of the new phase of Barbara Mascialino July 26 th 2004

2. July 26th, 2004INFN-Genova Barbara Mascialino Introduction First Phase First Phase already completed March 19 thLast March 19 th started Second Phase the Second Phase. Its aim is to bring the requirements resulting General Study from the General Study operative phase into an operative phase, software developing a software system system to fulfil them.

3. July 26th, 2004INFN-Genova Barbara Mascialino The simulation tool will useful be useful for space applications: - astronauts radioprotection, - airlines pilots radioprotection, - human presence in the space. HUMEX a study on the survivability and adaptation of humans to long-duration exploratory missions

4. July 26th, 2004INFN-Genova Barbara Mascialino Manyfold applications The outcome of the project would be relevant also for: biological experimentsbiological experiments radiotherapyradiotherapy radiobiologyradiobiology physicsphysics (micro and nano-dosimetric studies) technology transferfrom the space environment to the societytechnology transfer from the space environment to the society

5. July 26th, 2004INFN-Genova Barbara Mascialino Study plan 1 project environment1 : study of the project environment 2 application prototype2 : creation of a application prototype 3 application cellular DNA3 : development of the prototype and related components into an articulated application aimed at modelising the radiation effects at cellular and DNA levels.

6. July 26th, 2004INFN-Genova Barbara Mascialino United Software Development ProcessUnited Software Development Process RUP –practical guidance and tools from the RUP –mapping onto ISO 15504 Incremental and iterative life cycle model The software will be devolped through a series iterations of iterations, each one visiting all the main software disciplines Software process guidelines SPIRAL APPROACH

7. July 26th, 2004INFN-Genova Barbara Mascialino Deliverables ESA PSS-05 ESA PSS-05 software development standard: User Requirement Document - User Requirement Document Software Specification Document - Software Specification Document Software User Manual - Software User Manual Software Validation and Verification Plan - Software Validation and Verification Plan

8. July 26th, 2004INFN-Genova Barbara Mascialino Milestones SCIENTIFIC BACKGROUND PHASE 1 MILESTONE 1 SCIENTIFIC BACKGROUND USER REQUIREMENTS DOCUMENT PHASE 2 MILESTONE 2 USER REQUIREMENTS DOCUMENT PROTOTYPE PHASE 3 MILESTONE 3 PROTOTYPE SECOND ITERATION PHASE 4 MILESTONE 4 SECOND ITERATION THIRD ITERATION PHASE 5 MILESTONE 5 THIRD ITERATION

9. July 26th, 2004INFN-Genova Barbara Mascialino Milestone 1: September 19 th 2004 Study of: - Space radiation environment - ESA space projects - Existing physics models - Radiation effects on macroscopic biological structures - Radiation effects on microscopic biological structures - Existing bio-chemical models - Existing Monte Carlo codes WORK TEAM DEFINITION

10. July 26th, 2004INFN-Genova Barbara Mascialino Milestone 2: October 19 th 2004 - Review of functionality User Requirement Document -Review and update of the User Requirement Document produced during the First Phase First Phase of the study

11. July 26th, 2004INFN-Genova Barbara Mascialino Milestone 3: March 19 th 2006 First iteration: explorative prototype (verify capabilities to satisfy the User Requirements) - Update of the User Requirements - Study of the User Requirements - Design - Implementation - Test - Documentation

12. July 26th, 2004INFN-Genova Barbara Mascialino Milestone 4: March 19 th 2007 Secon iteration: Modelisation of radiation interactions with macroscopic biological structures Update of the User Requirements Study of the User Requirements Design Implementation Test Documentation Modelisation of radiation interactions with cellular structures Update of the User Requirements Study of the User Requirements Design Implementation Test Documentation Modelisation of radiation interactions with microscopic biological structures Update of the User Requirements Study of the User Requirements Design Implementation Test Documentation

13. July 26th, 2004INFN-Genova Barbara Mascialino Milestone 5: March 19 th 2008 Third iteration: Modelisation of radiation interactions with macroscopic biological structures Update of the User Requirements Study of the User Requirements Design Implementation Test Documentation Modelisation of radiation interactions with cellular structures Update of the User Requirements Study of the User Requirements Design Implementation Test Documentation Modelisation of radiation interactions with microscopic biological structures Update of the User Requirements Study of the User Requirements Design Implementation Test Documentation

14. July 26th, 2004INFN-Genova Barbara Mascialino “Finally” Cellular specialisation? Cellular position? Cellular status? Oxigen component?