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Published byRalf Robbins Modified over 9 years ago
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Metabolic Syndrome By: Dr.AP.Ahmed el-Shaer Dr.Mohamed El-Zayat
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Definition :
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Pathophysiology of Metabolic Syndrome 1-Central (Visceral) Obesity 2-Insulin Resistance 3-Atherogenic Dyslipidemia 4-Hypertension 5-Thrombogenicity 6-Inflammation and Endothelial Dysfunction
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Systemic Effects of Metabolic Syndrome Diabetes Acute stroke in the elderly. kidney Liver Pregnancy Surgical patient
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Insulin Resistance
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Strategies for Metabolic Management -Insulin Resistance and Hyperglycemia: A) Insulin secretagogues Sulfonylureas Nonsulfonylureas (repaglinide and nateglinide) B)Insulin-sensitizing agents Biguanides (metformin) PPAR- ligands (thiazolidinediones) -Atherogenic Dyslipidemia: HMG-CoA reductase inhibitors (statins) PPAR- ligands (fibrates) -Increased Blood Pressure: Inhibitors of the renin – angiotensin system B-Blockers Calcium channel antagonists
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Exercise and Mobilization Nutrition
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Anesthesia and Analgesia Volatile anesthetics Intravenous induction agents Opioids Neuraxial blockade
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Thank you
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