1. بسم الله الرحمن الرحيم

2. Leukocytes Leukopenia Leukocytosis

4. Leukopenia (Agranulocytosis) Myeloid stem cell suppression Ineffective granulopoisis Heriditary disorders, kostmann syn. Immune destruction Spleenic sequestration Peripheral destruction

5. Leukocytosis

8. Normal Lymph node

9. Lymphadenitis Acute nonspecific lym. Chronic non specific lym. –Follicular hyperplasia –Sinus histiocytosis –Paracortical hyperplasis

13. Neoplastic proliferation of leukocytes –Lymphomas –Leukemias –Plasmacell dyskerasia –Langerhans cell histiocytosis

14. Lymphoproliferative disorders Lymphomas Leukemias Plasma cell dyscrasia Lymphomas Leukemias Plasma cell dyscrasia

15. Myeloid Neoplasms Acute Leukemias Chronic Leukemias Myelodysplastic disorders Myeloproliferative disorders

16. Lymphomas Hodgkins lymphoma (HD) Non Hodgkins lymphoma (NHL)

17. Hodgkin's Lymphoma

27. Non Hodgkin's lymphoma

45. Leukemia Classification Acute Aml, ALL Chronic CML, CLL Acute Aml, ALL Chronic CML, CLL

46. Myeloblast Lymphoblast ChromatinFineClamp Nucleoli 3 – 51- 2 Granules Variable Non PA - + Tdt %5 % 95 Sudan Black +- Mpo + -

50. A.M.L

54. A.L.L

56. Myelo dysplastic syndromes Refractory anemia R.A with ring sideroblast R.A with excess blast Chronic myelomonocytic leukemia RAED in trans Formation CMML in trans Formation

61. Chronic myeloproliferative disorders CML P.V MMM disease E.T

67. Chronic lymphoproliferative disorders CLL PLL NHL HCL

70. Plasma Cell neoplasms Multiple myeloma Solitary plasmacytoma Waldenstorm macroglobulinemia Heavy chain diseases Primary Amiloidosis Monoclonal Gamma pathy U.S

76. Histiocytoses Langerhans H / HistiocytosisX Eosinophilic granuloma Acute disseminated H. ((Letterer – Siwe synd)) Hand schuller chrisrian disease

77. Morphologic aspects HLA – DR CDa Birbeck (HX) granules