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ThalassemiaNormal
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α-Thalassemia Trait
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Β-Thalassemia Trait
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Drawing of Thalassemia Major
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Thalassemia
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Alpha Thalassemia
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Normal v Sickle Cell
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Disease Mechanism
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AS v SS Hemoglobin
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Sickle Cell Anemia
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Hemoglobin C Disease
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Copyright ©2005 American Society of Hematology. Copyright restrictions may apply. Lazarchick, J. ASH Image Bank 2005;2005:101384 The "Washington monument" and rhomboid-shaped crystalline structures are shown
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Copyright ©2005 American Society of Hematology. Copyright restrictions may apply. Lazarchick, J. ASH Image Bank 2005;2005:101384 Peripheral smear from an 18 year old Black female who had a routine CBC performed as part of her prenatal laboratory studies
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Copyright ©2005 American Society of Hematology. Copyright restrictions may apply. An intact RBC with an eccentrically placed hemoglobin C crystal is noted in the center of the image
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S-C Disease
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Variation of SC forms
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SS SC CC
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Teardrop (Lacrymocyte)
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Myelofibrosis?
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Myelofibrosis
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Target Cells in Liver Disease
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Target Cells
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Liver Disease
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Severe Liver Disease
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Rouleaux Fomation
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Cold Agglutinin Disease
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Cold Agglutination (AIHA)
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Agglutination vs. Rouleaux
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Polychromasia
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Recticulocytes, Supravital stain
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Basophilic Stippling
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Lead Poisoning Coarse Basophilic Stippling
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NRBC and H-J Bodies
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Pappenheimer Bodies (Iron)
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Pappenheimer bodies
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Pappenheimers Wright v Iron Stain
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Pappenheimer v Basophilic Stippling
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Heinz bodies
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Cabot Ring
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Malaria
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Malaria, falciparum gametocyte
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Falciparum Gametocyte
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Vivax Gametocyte
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Ring forms
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Babesiosis
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Bacteria
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Review of RBC forms
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● 1. SS 12/97: many sickle cells, target cells, sphereocytes, few NRBC, polychromasia ● 2. SC: SC crystals, target cells, few sphereocytes, rare sickle cell ● 3. Sickle Cell 1993: sickle cells, polychromasia, rare NRBC ● 4. Baso Stip Polychrom: basophilic stippling, polychromasia, teardrop cells ● 5. alpha thal hgb H: hypo/micro, targets, teardrops, polychromasia, burr cells, schistocytes, reare spherocyte ● 6. Retic: new methylene blue stain. Reticulocytes visible ● 7. Thal 1997: many targets, many spherocytes, schistocytes, hypo/micro, bizzare morph ● 8. Hemoglobin CC: target cells, envelope cells, cc crystal ● 9. Liver Disease: target cells ● 10. Pappenheimer: pappenheimer bodies, burr cells, acnathocytes ● 11. Rouleaux: rouleaux ● 12. Falciparum Gametocytes: P. falciparum ● 13. Vivax gametocytes: P. vivax ● 14. Malaria: heavy infection, many rings ● 15. Malaria 1992: what do you see? ● 16. Lymph ● 17. Leuk Rx WBC 60K: increased neutrophils, some young ● 18. Borrellia: causitive agent of Lymes Disease ● 19. Yeast: budding yeast
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