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Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response by Selvakumar Subbian, Liana Tsenova, Guibin Yang, Paul O'Brien, Sven.

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Presentation on theme: "Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response by Selvakumar Subbian, Liana Tsenova, Guibin Yang, Paul O'Brien, Sven."— Presentation transcript:

1 Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response by Selvakumar Subbian, Liana Tsenova, Guibin Yang, Paul O'Brien, Sven Parsons, Blas Peixoto, Leslie Taylor, Dorothy Fallows, and Gilla Kaplan Open Biology Volume 1(4):110016 December 7, 2011 ©2011 by The Royal Society

2 Global transcriptome of Mtb-infected rabbit lungs. Selvakumar Subbian et al. Open Biol 2011;1:110016 ©2011 by The Royal Society

3 Expression kinetics of IFN-γ, IL-4, T- and B-cell activation network genes in HN878-infected rabbit lungs. Selvakumar Subbian et al. Open Biol 2011;1:110016 ©2011 by The Royal Society

4 qPCR analysis of macrophage-activation genes in HN878-infected rabbit lungs. Selvakumar Subbian et al. Open Biol 2011;1:110016 ©2011 by The Royal Society

5 qPCR analysis of genes involved in the Th1- and Th2-regulatory response in HN878-infected rabbit lungs. Selvakumar Subbian et al. Open Biol 2011;1:110016 ©2011 by The Royal Society

6 Activation of rabbit macrophages and T cells following HN878 infection. Selvakumar Subbian et al. Open Biol 2011;1:110016 ©2011 by The Royal Society

7 (a) Levels of anti-PPD immunoglobulin-G measured in the serum of HN878-infected rabbits. Selvakumar Subbian et al. Open Biol 2011;1:110016 ©2011 by The Royal Society

8 Histology of HN878-infected rabbit lung sections at 4 (a,b and b), 8 (c,d and d), 12 (e,f and f) and 16 (g,h and h) weeks post-infection stained by H&E (a–h) or by anti-IgG antibody for B cells (dark brown spots in b, d, f and h) and photographed at 4X (a,c... Selvakumar Subbian et al. Open Biol 2011;1:110016 ©2011 by The Royal Society


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