1. Project Sentinel Collaboratory Georgetown University Medical Center Washington Hospital Center Seong K. Mun, PhD Funded By National Library of Medicine

2. –We need a systematic way to provide –Indication and Warning (I&W) of impending threats from –infectious diseases across our –plants, –Animals and –human populations –So prevention can be rapidly undertaken ISIS Approach to Integrated Biodefense

3. WNV: Relatively Low Level Threat Excellent Model for Enviro-climatic Coupling of Pathogens Surrogate Model for Propagation of Mosquito Mediated Infectious Disease

4. 3 Source: CDC

5. (1995) “Conditions Favorable”: enviro-climatic signature tracks with epidemic Epidemic Start Point Epidemic End Point I&W : Venezuelan Equine Encephalitis

6. 1. Un-translated Chinese media document: “school”+”factory” “closings” 2.Telecommunication data: anomalies 3.Economic: trade restrictions I&W : SARS

7. Plant Pathogens Human Pathogens Animal Pathogens Zoonotic Pathogens “Factors of Disease Emergence” apply to all of these!

8. Problem Definition Human medical surveillance focused Minimal incorporation of I&Ws Alerting capability: days (mostly) to weeks (rarely) Limited geographic and topic coverage Stovepiped systems and mission statements No interface between I&W alerting and responder community What can IT do to address this problem?

9. Real Anthrax Cases in DC Flu Flu Flu I&W: Anthrax

10. ISIS Center Laboratory Hospital Home Global Environment Animals, Plants, Water Cyber Space and Human Space Hospital

11. Project Sentinel Collaboratory Linking Medical Information Systems of two different hospitals Public Health, Disease Surveillance and Geographic Information System Data Visualization and Medical Weather Service Federated Organizations and Biometrics Grid Service for Data Sharing and Interoperability Information Assurance

12. Partial IT for Project Sentinel Collaboratory ISIS Biodefense

13. 3 Infection Number Vs, Infection Rate  GIS Visualization: choropleth map  Difficult to assess DC

14. 3  GIS Visualization: “Micromap”  DC ranked 6 th in the nation for WNV infection risk

15. 3 Ward 3 identified as area of highest risk for infection Medical Vanguard

16. 3  Graded Alerting- Each I&W has a different level of significance that implies imminence of threat to humans Allowing more time to prepare for potential epidemics

17. Building a Wider Net Data from 100 Emergency Rooms  ScriptRx Transportation Pattern Data Electronic Communication Data 2000 Pet Clinics: Diagnostic Data Food Security Related Data

18. BioeventDiagnosis Pre-Event Peri-Event Post-Event Current US Strategy I&Ws I&Ws for bioevents offer weeks to months of lead time alerting… I&Ws prime the response system I&Ws and Current US Biosurveillance Strategy

19. Integrated Biodefense Situation Room Animal Situation RoomMedical Health Situation IT Infrastructure C. Peck

20. Technical Objectives Demonstrate the use of  Scalability  Network Aware  Geographic Information System To support applications in  Public Health  Medical Decision Making  Large Scale Health Emergency

21. Thank you.