1. Metabolic Activation Therapy Premilinary Information for Endocrinologists

4. High pulses of insulin found here, 200 to 1,000  U / ml. If you feed 100 grams of glucose to a normal man, high pulses of insulin will be found in the portal vein within a few minutes. ½ of all insulin stops in the liver on first pass. Note the remaining levels of insulin in the body, all are very blunted by the liver. In processing food into energy, the body needs certain enzyme pathways activated, and normal people with these can efficiently use glucose to produce energy (ATP). Maximum levels outside portal vein are 75  U/ml.

5. No high pulses of insulin ( 200 to 1,000  U / ml.) are found in diabetic portal vein If you feed 100 grams of glucose to a diabetic person, type 1 or type 2 there are no high pulses of insulin in the portal vein Maximum levels outside portal vein are 40  U/ml from shots.

6. The Biostator showed that proper metabolism can be achieved by stimulation of the liver. Note the high concentrations of insulin in the body (200-400) which are “covered” by IV glucose infusion. MAT ® therapy achieves these results without constant linkage to a Biostator and with treatments given only once per week.

7. Liver Controls Body’s Glucose

8. Sufficient Insulin in Portal Vein to Signal the Liver

11. ENZYMES INDUCED OR REPRESSED BY INSULIN ENZYMES INDUCED BY A HIGH INSULIN:GLUCAGON RATIO: –GLUCOKINASE –6-PHOSPHOFRUCTO 1-KINASE –6-PHOSPHOFRUCTO 2-KINASE –CITRATE CLEAVAGE ENZYME –ACETYL-COA CARBOXYLASE –HMG-COA REDUCTASE –PYRUVATE KINASE

12. 1.31/38 PATIENTS SUFFERED NEUROPATHY; 25/38 RENAL DISEASE; 24/38 EYE DISEASE; 20/38 HYPOGLYCEMIC UNAWARENESS; 14/38 HbA1c >8%; 5/38 GASTROPARESIS; 3/38 ORTHOSTATIC HYPOTENSION 2.9/38 WERE TYPE 2 AND 27/38 TYPE 1 PATIENTS 3.ALL PATIENTS HAD COMPLICATIONS DESPITE VIGOROUS ATTEMPTS AT TIGHT GLUCOSE CONTROL 4.ALL COMPLICATIONS SLOWED, STABILIZED OR REVERSED. 5.MANY PATIENTS ON WEEKLY TREATMENTS IMPROVED FOR THE FIRST SEVERAL YEARS 6.NO PATIENTS EXPERIENCED NEW COMPLICATIONS 7.IF PATIENTS STOP TREATMENT, COMPLICATIONS RETURN- MOST PATIENTS RETURN TO TREATMENT. 8.MAJOR IMPROVEMENTS IN QUALITY OF LIFE ALL PATIENTS LONG TERM ANECDOTAL RESULTS OF 38 PATIENTS TREATED FOR AN AVERGE OF 13 YEARS AT ADRI