1. Single molecule manipulation: magnetic tweezers INESC-MN Magnets (NdFeB) Magnets (NdFeB) Resolution 5 nm [ ] Seidel et al, Nature Structural & Molecular Biology 11, 838-843 (2004) 52nd MMM Conference – Tampa FL November 2007 FA-05 3/38 EcoR124I

2. INESC-MN 53rd MMM Conference – Austin TX November 2008 CG-05 Micro Fabricated Structures (Without Fluidic Chamber) Spin Valves & Magnetic Tunnel Junctions 6

3. Magnetic Tweezer, DNA manipulation, DNA translocation I AC I DC V +, I + V -, I - 10  m M.R. ATP FP6 BioMolSwitch

4. INESC-MN Optical  Scope – Vertical Switch 52nd MMM Conference – Tampa FL November 2007 FA-05 28/38 45 mA I MT 0 mA

5. INESC-MN 53rd MMM Conference – Austin TX November 2008 CG-05 7 Micro Fabricated Structures (Without Fluidic Chamber) Spin Valves & Magnetic Tunnel Junctions

6. INESC-MN 53rd MMM Conference – Austin TX November 2008 CG-05 Bead Detection Intermixing frequency 16